Results 61 to 70 of about 7,952,783 (243)
Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]
, 2020 Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles +3 more
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2005 Vascular endothelial growth factor. (VEGF) and its receptors. (FLT-1 and KDR) are overexpressed by human bladder cancer cells and tumor endothelial cells, respectively.
Khalid Mohamedali +9 more
doaj +1 more source
Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman +10 more
doaj +1 more source
The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]
, 2012 Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease. One feature of hypertension is a hyperresponsiveness to contractile agents, and inhibition of vasoconstriction forms the basis
Roberts, Richard E.
core +2 more sources
Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core
Cardiotoxicity with vascular endothelial growth factor inhibitor therapy [PDF]
, 2018 Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway (VSP) have been important additions in the therapy of various cancers, especially renal cell carcinoma and colorectal cancer.
Herrmann, Joerg, Touyz, Rhian M.
core +2 more sources
Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein
Biomedicines, 2017 Angiogenesis is a critical process in numerous diseases, and intervention in neovascularization has therapeutic value in several disease settings, including ocular diseases, arthritis, and in tumor progression and metastatic spread.
Khalid A. Mohamedali +1 more
doaj +1 more source
EBioMedicine, 2019 Background Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause of visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA and thus influencing mRNA expression in vascular ...
Ke Zhu +11 more
semanticscholar +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source