Results 171 to 180 of about 1,741 (203)

Vascular changes in vascularized composite allotransplantation

Current Opinion in Organ Transplantation
Purpose of review Allograft vasculopathy in vascularized composite allografts (VCA) remains understudied. This review explores the vascular changes in VCA, focused on recent literature. Recent findings Allograft vasculopathy in VCA generally includes progressive concentric ...
Ethan Y, Song, Brooke E, Barrow, Linda C, Cendales   +2 more
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Chronic rejection in vascularized composite allotransplantation

Current Opinion in Organ Transplantation, 2018
Purpose of reviewVascularized composite allografts (VCA), which restore severely damaged body parts that cannot be repaired with conventional surgical techniques, often undergo acute skin rejection episodes in the early postgraft period. Although the risk of human VCA to be affected by chronic rejection was initially unknown, such cases were recently ...
Morelon E, Petruzzo P, Kanitakis J.
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Mechanisms of rejection in vascular composite allotransplantation

Current Opinion in Organ Transplantation, 2018
For patients with devastating injuries in whom standard reconstruction is not an option, vascularized composite allotransplantation (VCA) has become a viable means of restoring form and function. However, immunological rejection continues to be a problem in VCA and has not yet been fully characterized.
Joanna W, Etra, Giorgio, Raimondi, Gerald, Brandacher   +2 more
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Vascularized Composite Allotransplantation and Tissue Engineering

Journal of Craniofacial Surgery, 2013
For many living with the devastating aftermath of disfiguring facial injuries, extremity amputations, and other composite tissues defects, conventional reconstruction offers limited relief. Full restoration of the face or extremities with anatomic equivalents recently became possible with decades of advancements in transplantation and regenerative ...
Ericka M, Bueno, J Rodrigo, Diaz-Siso, Geoffroy C, Sisk, Akash, Chandawarkar, Harriet, Kiwanuka, Brooke, Lamparello, Edward J, Caterson, Bohdan, Pomahac   +7 more
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Vascularized Composite Allotransplantation

2009
Vascularized composite allotransplantation is a field in its early development. This chapter describes the latest classification scheme applied to composite grafts and acute cellular rejection is amply demonstrated with high quality images. The differential diagnosis of mimics of rejection in the skin and a brief account of the immunologic mediators of
Linda C. Cendales, Jean Kanitakis, Carolyn Burns   +2 more
openaire   +1 more source

Vascular Considerations in Composite Midfacial Allotransplantation

Plastic and Reconstructive Surgery, 2010
Advances in microsurgery and immunosuppression have allowed for facial reconstruction at a qualitatively new level with facial composite tissue allografts. Although donor tissue recovery is unique for each patient, transplantation of the maxilla and overlying soft tissues will be a frequent indication. Vascularity of the maxilla and palate, supplied by
Bohdan, Pomahac, Benoit, Lengele, Emily B, Ridgway, Evan, Matros, Brian T, Andrews, Jason S, Cooper, Richard, Kutz, Julian J, Pribaz   +7 more
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Vascularized Composite Allotransplantation

2017
In order to discuss the ethics of vascularized composite allotransplantation (VCA) , it is necessary to have a firm grasp of this rapidly developing field, including its history, its present state and its anticipated future directions. The story of the development of VCA began in the imaginations of ancient peoples, but required important medical and ...
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Ischemia-Reperfusion Injury in Vascularized Composite Allotransplantation

Journal of Craniofacial Surgery, 2013
Vascularized composite allotransplantation may now be considered a viable treatment option in patients with complex craniofacial and limb defects. However, the field is still in its infancy, and challenges continue to exist. These challenges, most notably the adverse effects of lifelong immunosuppression, must be weighed against the benefits of the ...
Edward J, Caterson, Joseph, Lopez, Miguel, Medina, Bohdan, Pomahac, Stefan G, Tullius   +4 more
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Vascularized Composite Allotransplantation: Alternatives and Catch-22s

Plastic & Reconstructive Surgery, 2018
Summary: Technical success has been achieved in several forms of vascularized composite allotransplantation, including hand, face, penis, and lower extremity. However, the risks of lifelong immunosuppression have limited these procedures to a select group of patients for whom nontransplant alternatives have resulted in ...
J Rodrigo, Diaz-Siso, Zachary M, Borab, Natalie M, Plana, Brendan, Parent, John T, Stranix, Eduardo D, Rodriguez   +5 more
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Cell-Based Therapies in Vascularized Composite Allotransplantation

Journal of Reconstructive Microsurgery, 2018
Background Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells with tolerogenic function. The ability of DCs to regulate alloantigen-specific T cell responses and to promote tolerance has aligned them ideally for a role in vascularized composite allotransplantation (VCA).
Krishna S, Vyas, Anita T, Mohan, Shane D, Morrison, Duy C, Tran, Samir, Mardini   +4 more
openaire   +2 more sources