Results 121 to 130 of about 920,092 (279)

Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah, Alaa Abdelhamid, Omar Tluli, Yaman Al‐Haneedi, Mera Abu Hussien, Ali H. Eid   +5 more
wiley   +1 more source

Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development

iScience
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is composed of heterogenous populations of neurons that express signaling peptides such as vasoactive intestinal polypeptide (VIP) and arginine vasopressin (AVP) and regulate circadian rhythms in ...
Masatoshi Hirayama, Ludovic S. Mure, Hiep D. Le, Satchidananda Panda   +3 more
doaj   +1 more source

Sex‐Dependent Alterations in Behavioral Development of Mice Lacking α5‐Nicotinic Acetylcholine Receptors

Journal of Neuroscience Research, Volume 104, Issue 10, October 2026.
Loss of α5‐nAChRs drives age‐dependent, sex‐specific behavioral alterations, with females showing early cognitive deficits and males a progressive decline. These findings identify α5‐nAChRs as key regulators of neural circuit maturation and underscore the critical importance of incorporating sex as a biological variable in preclinical research ...
Danai Papavranoussi Daponte, Filippos Marinos, Eleni Matala, Irini Skaliora   +3 more
wiley   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma

Journal of Indian Association of Pediatric Surgeons
We present a rare case of a 17-month-old child diagnosed with MS-stage neuroblastoma and associated chronic diarrhea due to elevated vasoactive intestinal peptide (VIP) levels.
Josy Thomas, Nitin James Peters, Aravind Sekar, Deepak Bansal, Jitender Singh, Ravi P. Kanojia, J. K. Mahajan   +6 more
doaj   +1 more source

A Cohort Study on Incidence and Factors Associated With Adverse Drug Reactions of Enalapril in Lusaka, Zambia

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Angiotensin‐converting enzyme inhibitors (ACEIs) are widely prescribed but are associated with adverse drug reactions (ADR), including angioedema, which is typically reported in 0.1%–0.7%. Data from sub‐Saharan Africa are limited. This study aimed to estimate the incidence and risk factors of enalapril‐associated ADRs in a Zambian cohort, with
Ntemena Yikon'a, Ngosa Mumba, Sarah Pedretti, Helen Hoenck, Jonathan Peter, Owen Ngalamika   +5 more
wiley   +1 more source

From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer’s disease treatment

Current Research in Biotechnology
Alzheimer’s Disease (AD) represents a significant neurodegenerative challenge with current therapeutic strategies primarily focused on symptomatic management.
Artur Galushkin, Illana Gozes
doaj   +1 more source

Glucagon‐Like Peptide‐1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Incretin effect helps in regulating glucose homeostasis and maintaining glycaemic control within the human body. This effect is achieved by the two naturally occurring incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1).
Nora H. J. Alharbi
wiley   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, Volume 59, Issue 10, Page 2028-2045, October 2026.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source