Results 81 to 90 of about 22,615 (195)

Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases

The Journal of Dermatology, Volume 53, Issue 7, Page 967-979, July 2026.
ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Characteristics, management, and outcomes of patients with VIPoma–A retrospective analysis of the ENETS database

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Introduction: VIPoma is an extremely rare functioning pancreatic neuroendocrine tumor. Therefore, data regarding treatment and outcome are very limited. Aim (s): This multicenter study aimed to analyze clinical characteristics, real‐world management, and outcomes of patients with VIPoma.
Detlef K. Bartsch, L. Mais, L. de Mestier, E. Baudin, G. Kaltsas, J. Hofland, R. Garcia‐Carbonero, E. Tiensuu Janson, M. G. McNamara, M. Andreassen, S. Grozinsky‐Glasberg, F. Spada, H. Leupe, F. Panzuto, M. Fleschen, H. Klinkhammer   +15 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source

Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development

iScience
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is composed of heterogenous populations of neurons that express signaling peptides such as vasoactive intestinal polypeptide (VIP) and arginine vasopressin (AVP) and regulate circadian rhythms in ...
Masatoshi Hirayama, Ludovic S. Mure, Hiep D. Le, Satchidananda Panda   +3 more
doaj   +1 more source

Vasoactive Intestinal Polypeptide Secreting MS Neuroblastoma

Journal of Indian Association of Pediatric Surgeons
We present a rare case of a 17-month-old child diagnosed with MS-stage neuroblastoma and associated chronic diarrhea due to elevated vasoactive intestinal peptide (VIP) levels.
Josy Thomas, Nitin James Peters, Aravind Sekar, Deepak Bansal, Jitender Singh, Ravi P. Kanojia, J. K. Mahajan   +6 more
doaj   +1 more source

From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer’s disease treatment

Current Research in Biotechnology
Alzheimer’s Disease (AD) represents a significant neurodegenerative challenge with current therapeutic strategies primarily focused on symptomatic management.
Artur Galushkin, Illana Gozes
doaj   +1 more source

Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Терапевтический архив
Aim. To determine the role of the expression of motilin and vasoactive intestinal peptide (VIP) in diverticular disease of the large intestine (DD). Materials and methods. Examined 45 patients with DD.
Mikhail A. Osadchuk, Ekaterina D. Mironova, Iuliia S. Krylova, Pavel V. Gulyaev, Regina A. Akhtyamova   +4 more
doaj   +1 more source