Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries [PDF]
Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization (high K+)-, and mechanical ...
Abramowitz, Joel+6 more
core +12 more sources
Mechanisms of electrical vasoconstriction [PDF]
Electrical vasoconstriction is a promising approach to control blood pressure or restrict bleeding in non-compressible wounds. We explore the neural and non-neural pathways of electrical vasoconstriction in-vivo.Charge-balanced, asymmetric pulses were delivered through a pair of metal disc electrodes.
Mark Brinton+3 more
openaire +4 more sources
A NONLINEAR MODEL FOR VASOCONSTRICTION [PDF]
Abstract The control of blood pressure is a complex mixture of neural, hormonal and intrinsic interactions at the level of the heart, kidney and blood vessels. While experimental approaches to understanding these interactions remain useful, it remains difficult to conduct experiments to quantify these interactions as the number of parameters ...
Ringwood, John+3 more
openaire +4 more sources
Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay [PDF]
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy ...
Ashton RE+17 more
core +1 more source
The effect of ethnicity on the vascular responses to cold exposure of the extremities [PDF]
This is an accepted manuscript of an article published by Springer in European Journal of Applied Physiology on 01/08/2014, available online: https://doi.org/10.1007/s00421-014-2962-2 The accepted version of the publication may differ from the final ...
Eglin, CM+3 more
core +3 more sources
Sympathetic nerve-derived ATP regulates renal medullary vasa recta diameter via pericyte cells: a role for regulating medullary blood flow? [PDF]
Pericyte cells are now known to be a novel locus of blood flow control, being able to regulate capillary diameter via their unique morphology and expression of contractile proteins.
Crawford, C.+4 more
core +2 more sources
Postsynaptic α1-Adrenergic vasoconstriction is impaired in young patients with vasovagal syncope and is corrected by nitric oxide synthase inhibition [PDF]
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope (VVS).
Medow, MS+6 more
core +1 more source
Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. [PDF]
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death.
Ayako Makino+5 more
core +9 more sources
An Intact Kidney Slice Model to Investigate Vasa Recta Properties and Function in situ [PDF]
Background: Medullary blood flow is via vasa recta capillaries, which possess contractile pericytes. In vitro studies using isolated descending vasa recta show that pericytes can constrict/dilate descending vasa recta when vasoactive substances are ...
Agmon Y+51 more
core +2 more sources
Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1% [PDF]
Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders.
Ayres JW+30 more
core +1 more source