Results 111 to 120 of about 112,252 (265)

Anastomotic Failure Is Not Affected by Anastomotic Technique in Minimally Invasive Two‐Stage Oesophagectomy

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background The choice of anastomotic technique in minimally invasive oesophagectomy (MIO) may influence postoperative morbidity and long‐term outcomes. The primary aim of our study is to determine whether circular (CS) or linear‐stapled (LS) anastomosis is associated with anastomotic complications following MIO.
L. Vu, C. Cabalag, L. Ng, B. Choo, A. Hardley, S. Kariyawasam   +5 more
wiley   +1 more source

Facilitators, Barriers and Reported Implementation Outcomes of Wide‐Awake Local Anaesthesia No Tourniquet in Hand Surgery Practice: A Systematic Scoping Review

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Wide‐Awake Local Anaesthesia No Tourniquet (WALANT) is increasingly being used by hand surgeons. This systematic scoping review aims to identify and collate existing evidence on the reported implementation outcomes, barriers, facilitators and implementation strategies relevant to WALANT in hand surgery practice. Methods A systematic
Freya Roberts, Ali Gholamrezaei, Brett McClelland, Dion Sandoz, Tanya Burgess   +4 more
wiley   +1 more source

Magnetic Resonance Imaging Evaluation of Functional Differences Between In Vivo Human Kidneys and Discarded Human Kidneys During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
Comparative MRI of in vivo kidneys and ex vivo donor kidneys during NMP revealed marked physiological differences and limited correspondence with conventional perfusion or injury metrics. These distinct ex vivo MRI signatures emphasize the need to consider parameters beyond conventional in vivo functional markers when assessing organ viability during ...
Tim L. Hamelink, Chris L. Jaynes, L. Annick van Furth, Johannes Castelein, Nathan Ooms, Veerle A. Lantinga, Baran Ogurlu, Xiaopeng Zhou, Ulrike Dydak, Henri G. D. Leuvenink, Anna Krarup Keller, Ronald J. H. Borra, Cyril Moers   +12 more
wiley   +1 more source

Limited Evidence of Noradrenaline Use and Effectiveness in Preterm Neonates: A Systematic Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The study aimed to analyse the effects and associated outcomes of noradrenaline in treating hypotension in preterm neonates. Methods We searched PubMed, Web of Science, and Scopus to August 2025 for randomised and observational studies on noradrenaline use in preterm neonates.
A. Vänskä, U. Sankilampi, I. Kuitunen
wiley   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Commentary: Vasopressors in Early Burn Resuscitation: Physiological Concerns Revisited. [PDF]

Acta Anaesthesiol Scand
Sjoberg F, Vuola J, Lindford A, Palmieri T, Elmasry M, El-Serafi AT, Steinvall I.   +6 more
europepmc   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Timing of Delivery in Preeclampsia: Time to Reconsider?

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Rebecca Horgan, Ahmed S. Z. Moustafa, Mackenzi Mchugh, Tetsuya Kawakita, Baha Sibai, George Saade   +5 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source