Results 191 to 200 of about 172,620 (346)

DEPRESSION OF HYPOXIC PULMONARY VASOCONSTRICTION IN THE DOG BY DOPAMINE AND ISOPRENALINE

open access: bronze, 1979
Jean‐Grégoire Marin   +3 more
openalex   +1 more source

Progress on the development of Class A GPCR‐biased ligands

open access: yesBritish Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales   +20 more
wiley   +1 more source

Corticosteroid-Induced Vasoconstriction Studied by Xenon 133 Clearance

open access: bronze, 1973
Terrence P. Greeson   +3 more
openalex   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin   +6 more
wiley   +1 more source

Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 11, Page 2503-2523, June 2025.
Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla   +7 more
wiley   +1 more source

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