Results 201 to 210 of about 146,147 (346)

Prescribing Inflammatory Bowel Disease Medications in Chronic Kidney Disease: A Practical Guide

open access: yesAlimentary Pharmacology &Therapeutics, Volume 62, Issue 4, Page 400-418, August 2025.
Most therapies used in inflammatory bowel disease appear safe and effective when used in chronic kidney disease including on renal replacement therapy, particularly biologic therapies. Some caution should be considered when using conventional therapies and JAK inhibitors.
Lynna Chen   +6 more
wiley   +1 more source

Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome‐Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical Studies

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
In a pooled analysis, bradycardia was observed in 6% of terlipressin‐treated patients but rarely required a dose interruption or reduction. Arrhythmia serious adverse event incidences were low and similar in both treatment groups. Routine intensive cardiac monitoring for the detection of arrhythmias may not be necessary during terlipressin ...
Jasmohan S. Bajaj   +6 more
wiley   +1 more source

Cerebrovascular Responses in a Patient with Lundberg B Waves Following Subarachnoid Haemorrhage Assessed with a Novel Non-Invasive Brain Pulse Monitor: A Case Report

open access: yesMedical Devices: Evidence and Research
Elliot John Teo,1,2 Sigrid Petautschnig,1,2 Jack Hellerstedt,1 Sally A Grace,1 Jacqui S Savage,1 Brendan Fafiani,1 Paul Daniel Smith,3,4 Ashu Jhamb,5 Timothy Haydon,2,6 Barry Dixon1,5,6 1Cyban Pty Ltd, Melbourne, Victoria, Australia; 2Department of ...
Teo EJ   +9 more
doaj  

Refining Prognosis in Cirrhosis Patients With Ascites: Impact of Acute vs. Non‐Acute Decompensation

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
The novel classification of acute and non‐acute decompensation provides prognostic information, but the role of hospitalisation status should be reconsidered. ABSTRACT Background A more granular understanding of hepatic decompensation in cirrhosis has led to the classification of acute decompensation (AD) and non‐acute decompensation (NAD).
Lucie Simonis   +19 more
wiley   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post   +4 more
wiley   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin   +6 more
wiley   +1 more source

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 channels to control artery tone and capillary diameter

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye   +5 more
wiley   +1 more source

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