Results 291 to 300 of about 172,620 (346)

Maternal high glucose and fat diet exposure impaired vascular constriction via miR-325-3P/SHIP2/NOX2 pathway axis in offspring vessels. [PDF]

open access: yesCell Mol Life Sci
Ji B   +10 more
europepmc   +1 more source

The heart, a secondary organ in the control of blood circulation

open access: yesExperimental Physiology, Volume 110, Issue 5, Page 649-665, 1 May 2025.
Abstract Circulation of the blood is a fundamental physiological function traditionally ascribed to the pressure‐generating function of the heart. However, over the past century the ‘cardiocentric’ view has been challenged by August Krogh, Ernst Starling, Arthur Guyton and others, based on haemodynamic data obtained from isolated heart preparations and
Branko Furst, José González‐Alonso
wiley   +1 more source

Cardiac output‐mediated regulation of cerebral blood flow during exercise: Clinical perspectives on the indirect impact of muscle metaboreflex

open access: yesExperimental Physiology, Volume 110, Issue 5, Page 686-693, 1 May 2025.
Abstract The muscle metaboreflex stimulates the elevation of arterial blood pressure, aiming to rectify the oxygen deficit by enhancing oxygen delivery to support muscle activity. Moreover, activating the muscle metaboreflex significantly increases cardiac output (CO) by increasing factors such as heart rate, ventricular contractility, preload, stroke ...
Shigehiko Ogoh
wiley   +1 more source

Mechanisms mediating muscle metaboreflex control of cardiac output during exercise: Impaired regulation in heart failure

open access: yesExperimental Physiology, Volume 110, Issue 5, Page 675-685, 1 May 2025.
Abstract The ability to increase cardiac output during dynamic exercise is paramount for the ability to maintain workload performance. Reflex control of the cardiovascular system during exercise is complex and multifaceted involving multiple feedforward and feedback systems.
Donal S. O'Leary, Joseph Mannozzi
wiley   +1 more source

Running on empty: Factors underpinning impaired cardiac output reserve in heart failure with preserved ejection fraction

open access: yesExperimental Physiology, Volume 110, Issue 5, Page 694-707, 1 May 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is frequently attributed etiologically to an underlying left ventricular (LV) diastolic dysfunction, although its pathophysiology is far more complex and can exhibit significant variations among patients. This review endeavours to systematically unravel the pathophysiological heterogeneity
Paula Sagmeister   +8 more
wiley   +1 more source

Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest

open access: yesExperimental Physiology, EarlyView.
Abstract A reduction in cerebral blood flow (CBF) has been observed during spaceflight and bed rest. We aimed to examine the magnitude and regional heterogeneity of the decrease in CBF during bed rest compared to posture changes on Earth. Seventeen participants (age, 29 ± 9 years, 7 females) were studied in the upright and supine posture and over 3 ...
Carmen Possnig   +8 more
wiley   +1 more source

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