Results 101 to 110 of about 3,245,375 (355)

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom, Foster, Elyse, Harris, Debra S, Jacob, Peyton, Jones, Reese T, McGlothlin, Dana, Mendelson, John E   +6 more
core   +2 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

USE OF FLUIDS AND VASOPRESSORS IN THE PREVENTION AND MANAGEMENT OF THE SPINAL ANESTHESIA-INDUCED HYPOTENSION DURING SCHEDULED CESAREAN SECTION IN COLOMBIAN WOMEN (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: during the scheduled cesarean section, the main side effect of the spinal anesthesia is the spinal anesthesia-induced hypotension (SAIH).
Marrugo-Marrugo José, Granados-Vergara Lina, Marrugo-Vergara Jahaira   +2 more
doaj  

Prediction of vasopressor needs in hypotensive emergency department patients using serial arterial blood pressure data with deep learning

Hong Kong Journal of Emergency Medicine
Background Shock is a life‐threatening condition that is associated with high mortality and morbidity. Therefore, the timely identification and management of this condition are important.
Yeongho Choi, Ki Hong Kim, Yoonjic Kim, Dong Hyun Choi, Yoon Ha Joo, Sae Won Choi, Kyoung Jun Song, Sang Do Shin   +7 more
doaj   +1 more source

Non-invasive assessment of pulmonary vascular resistance in pulmonary hypertension: Current knowledge and future direction [PDF]

, 2017
Pulmonary Hypertension (PHT) is relatively common, dangerous and under-recognised. Pulmonary hypertension is not a diagnosis in itself; it is caused by a number of differing diseases each with different treatments and prognoses.
Hills, G, Kuppusamy, H, Naing, P, Playford, D, Scalia, G   +4 more
core   +2 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Cardiovascular complications following chronic treatment with cocaine and testosterone in adolescent rats. [PDF]

PLoS ONE, 2014
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown.
Sheila A Engi, Fábio C Cruz, Rodrigo M Leão, Luís C Spolidorio, Cleopatra S Planeta, Carlos C Crestani   +5 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Applicability of Vasopressor Trials in Adult Critical Care: A Prospective Multicentre Meta-Epidemiologic Cohort Study

Clinical Epidemiology, 2022
Nina Buchtele,1 Michael Schwameis,2 Dominik Roth,2 Franz Schwameis,3 Felix Kraft,4 Roman Ullrich,4 Jakob Mühlbacher,5 Roberta Laggner,6 Gunnar Gamper,7 Georg Semmler,8 Christian Schoergenhofer,9 Thomas Staudinger,1 Harald Herkner2 1Department of Medicine
Buchtele N, Schwameis M, Roth D, Schwameis F, Kraft F, Ullrich R, Mühlbacher J, Laggner R, Gamper G, Semmler G, Schoergenhofer C, Staudinger T, Herkner H   +12 more
doaj  

On Networks with Active and Passive Agents [PDF]

arXiv, 2014
We introduce an active-passive networked multiagent system framework, which consists of agents subject to exogenous inputs (active agents) and agents without any inputs (passive agents), and analyze its convergence using Lyapunov stability.
arxiv