Results 141 to 150 of about 9,502 (211)
Thermal adaptation of pelage in desert rodents balances cooling and insulation
Evolution, Volume 76, Issue 12, Page 3001-3013, December 2022., 2022 Abstract Phenotypic convergence across distantly related taxa can be driven by similar selective pressures from the environment or intrinsic constraints. The roles of these processes on physiological strategies, such as homeothermy, are poorly understood.
Eric A. Riddell +2 more
wiley +1 more source
Heat Stress and Placental Abruption: A Space–Time Stratified Case‐Crossover Study
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To examine whether heat stress, measured by wet bulb globe temperature (WBGT), a comprehensive heat stress index is associated with placental abruption within 7 days. Design A space–time‐stratified case‐crossover design. Setting All 11 regions in Japan during the warm season (June–September) from 2011 to 2020.
Shuhei Terada +3 more
wiley +1 more source
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. [PDF]
, 1994 Helmut O. Steinberg +4 more
openalex +1 more source
Rheocarna treatment for non‐dialysis patients
Therapeutic Apheresis and Dialysis, EarlyView.Abstract Introduction Rheocarna has attracted attention as an alternative therapy for severe chronic limb‐threatening ischemia, and there have been reports of its usefulness. However, most of these reports have been on dialysis patients, and there are few reports on the treatment conditions and efficacy in non‐dialysis patients.
Atsushi Ohkubo +11 more
wiley +1 more source
Vasodilation by Medroxalol Mediated by β2-Adrenergic Receptor Stimulation
, 1983 Richard C. Dage +2 more
openalex +1 more source
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. [PDF]
, 1991 Erling A. Anderson +4 more
openalex +1 more source
Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice
Aging Cell, EarlyView.The diminished function of endothelial TRPV4, rather than changes in its expression, plays a significant role in aging‐related endothelial dysfunction. The interaction between TRPV4 and GPR35 significantly contributes to this condition. Blocking the TRPV4‐GPR35 interaction with Thonningianin A or Carfilzomib represents a promising precision approach ...
Xiaoxue Tian +12 more
wiley +1 more source
Aging Cell, EarlyView.Aged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Qingqing Dai +5 more
wiley +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source