Results 121 to 130 of about 174,305 (306)

Spironolactone Induces Vasodilation by Endothelium-Dependent Mechanisms Involving NO and by Endothelium-Independent Mechanisms Blocking Ca²⁺ Channels

Journal of Xenobiotics
Background: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases (CVD) and is non-specific for mineralocorticoid receptors (MR) and with an affinity for progesterone (PR) and androgen (AR) receptors.
Margarida Lorigo, João Amaro, Elisa Cairrao   +2 more
doaj   +1 more source

The effect of acute consumption of a flavonol-rich cocoa drink on cerebral vasomotor reactivity in African Americans [PDF]

, 2014
textAfrican Americans (AA) are at great risk of cardiovascular diseases (CVD) which can lead to brain damage, dementia, and endothelial dysfunction.
Ku, ByungMo
core  

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Modeling of Blood Flow Dynamics in Rat Somatosensory Cortex

Biomedicines
Background: The cerebral microvasculature forms a dense network of interconnected blood vessels where flow is modulated partly by astrocytes. Increased neuronal activity stimulates astrocytes to release vasoactive substances at the endfeet, altering the ...
Stéphanie Battini, Nicola Cantarutti, Christos Kotsalos, Yann Roussel, Alessandro Cattabiani, Alexis Arnaudon, Cyrille Favreau, Stefano Antonel, Henry Markram, Daniel Keller   +9 more
doaj   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

PGI2-Aerosol versus nitric oxide for selective pulmonary vasodilation in hypoxic pulmonary vasoconstriction [PDF]

, 1993
Habazettl, H., Messmer, Konrad, Welte, M., Zwißler, Bernhard   +3 more
core   +1 more source

Reframing the role of glucagon‐like peptide 1 receptor agonists in cardiovascular medicine

ESC Heart Failure, Volume 12, Issue 2, Page 923-926, April 2025.
Riccardo M. Inciardi, Alvin Chandra, Ambarish Pandey, Marco Metra   +3 more
wiley   +1 more source

Ultrasound–triggered tumor‐selective nitric oxide release enhances tumor penetration of antibody–conjugated nanomedicine

Interdisciplinary Medicine, EarlyView.
Ultrasound‐triggered nitric oxide release from S‐nitrosated hyaluronic acid (HA‐SNO) induces tumor vasodilation and disrupts the vascular barrier, potently enhancing the intratumoral penetration of antibody‐conjugated nanomedicines. Abstract The tumor vascular barrier restricts the penetration of antibody‐conjugated nanomedicine, severely limiting its ...
Xiaodong Wang, Ruifeng Duan, Xin Chen, Tongjun Liu, Zhilin Liu   +4 more
wiley   +1 more source

Viscum album L. mother tinctures modulate Na+/K+ ATPase activity and expression, and promote endothelium-dependent vasodilation via SK channel and nitric oxide signalling

Frontiers in Physiology
IntroductionEthanolic extracts of Viscum album L. (European mistletoe), known as mother tinctures (VAMTs), have been used in traditional medicine to treat hypertension and cardiovascular diseases.
Rodrigo dos Santos Pinto Duarte, Michelle Nonato de Oliveira Melo, João V. C. Batista, Giovanna Gomes Martins, Adriana Passos Oliveira, Rosilane Taveira-da-Silva, Maria Luiza Fidelis da Silva, Rafael H. F. Valverde, Marcelo Einicker-Lamas, Arquimedes Gasparotto Junior, Stephan Baumgartner, Stephan Baumgartner, Stephan Baumgartner, Carla Holandino, Carla Holandino   +14 more
doaj   +1 more source