Results 21 to 30 of about 140,646 (292)

Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Short-term infusions of single vasodilators, usually given in a fixed dose, have not improved outcomes in patients with acute heart failure (AHF).
N. Kozhuharov, A. Goudev, D. Flores, M. Maeder, J. Walter, S. Shrestha, D. Gualandro, M. T. de Oliveira Junior, Z. Sabti, B. Müller, M. Noveanu, T. Socrates, R. Ziller, A. Bayés‐Genís, A. Sionis, P. Simon, E. Michou, S. Gujer, T. Gori, P. Wenzel, O. Pfister, D. Conen, I. Kapos, R. Kobza, H. Rickli, T. Breidthardt, T. Münzel, P. Erne, C. Mueller   +28 more
semanticscholar   +1 more source

The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2023
IntroductionThe disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP).
Yanna Tian, Katie Anne Fopiano, Vadym Buncha, Liwei Lang, Hayden A. Suggs, Rongrong Wang, R. Daniel Rudic, Jessica A. Filosa, Zsolt Bagi   +8 more
doaj   +1 more source

A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain

Journal of Neuroscience, 2017
Cerebral blood flow (CBF) is controlled by arterial blood pressure, arterial CO2, arterial O2, and brain activity and is largely constant in the awake state.
C. Howarth, B. Sutherland, Hyun B Choi, Chris J. Martin, B. Lind, Lila Khennouf, J. LeDue, J. Pakan, R. Ko, G. Ellis‐Davies, M. Lauritzen, N. Sibson, A. Buchan, B. MacVicar   +13 more
semanticscholar   +1 more source

Fast Isolation of Flavonoids from the Endemic Species Nolana ramosissima I.M. Johnst and Its Endothelium-Independent Relaxation Effect in Rat Aorta

Molecules, 2020
The infusion of the desertic plant Nolana ramosissima I.M. Johnst showed vascular smooth muscle relaxation in rat aorta and the presence of several phenolic compounds, which were detected by high resolution UHPLC-Orbitrap-HESI-MS.
Fredi Cifuentes, Javier Palacios, Jorge Bórquez, Adrián Paredes, Claudio Parra, Alejandra Bravo, Mario J. Simirgiotis   +6 more
doaj   +1 more source

Current concepts of active vasodilation in human skin

Temperature, 2016
In humans, an increase in internal core temperature elicits large increases in skin blood flow and sweating. The increase in skin blood flow serves to transfer heat via convection from the body core to the skin surface while sweating results in ...
B. Wong, Casey G. Hollowed
semanticscholar   +1 more source

Dipeptidyl Peptidase‐4 Inhibition Potentiates Stimulated Growth Hormone Secretion and Vasodilation in Women

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDiminished growth hormone (GH) is associated with impaired endothelial function and fibrinolysis. GH‐releasing hormone is the primary stimulus for GH secretion and a substrate of dipeptidyl peptidase‐4.
Jessica R. Wilson, Nancy J. Brown, Hui Nian, Chang Yu, Martin Bidlingmaier, Jessica K. Devin   +5 more
doaj   +1 more source

Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs

Hypertension in Pregnancy, 2022
Placental growth factor (PlGF), a member of the vascular endothelial growth factor family of proteins regulating angiogenesis, has been shown to have acute vasodilatory effects on human resistance arteries.
Adelene Y. Tan, Ken Kearney, Courtney Jenkins, S. Ananth Karumanchi, Walter Bee, Paul Kussie   +5 more
doaj   +1 more source

Novel 3D‐Printed Biophotonic Scaffold Displaying Luminescence under Near‐Infrared Light for Photopharmacological Activation and Biological Signaling Compound Release

Advanced Healthcare Materials, EarlyView.
Despite significant efforts in developing novel biomaterials to regenerate tissue, only a few of them have successfully reached clinical use. It has become clear that the next generation of biomaterials must be multifunctional. Smart biomaterials can respond to environmental or external stimuli, interact in a spatial‐temporal manner, and trigger ...
Sonya Ghanavati, Ekin Opar, Virginia Alessandra Gobbo, Carlo Matera, Fabio Riefolo, Rossella Castagna, Julien Colombelli, Andrew Draganski, Joshua Baggott, Mika Lastusaari, Pau Gorostiza, Laeticia Petit, Jonathan Massera   +12 more
wiley   +1 more source

Shenfu Injection Promotes Vasodilation by Enhancing eNOS Activity Through the PI3K/Akt Signaling Pathway In Vitro

Frontiers in Pharmacology, 2020
Vasomotor dysfunction is one of the key pathological aspects of shock and heart failure (HF). Shenfu injection (SFI) has been widely used for the treatment of shock and HF in China.
Jinqiang Zhu, Jinqiang Zhu, Wanshan Song, Shixin Xu, Shixin Xu, Yan Ma, Baoyu Wei, Baoyu Wei, Hongwu Wang, Shengyu Hua, Shengyu Hua, Shengyu Hua   +11 more
doaj   +1 more source

Hydrocolloid‐Based Multiwavelength Stretchable QD‐OLED Patch for Simultaneous Neonatal Jaundice and Dermatitis Treatment with Biosignal Monitoring

Advanced Healthcare Materials, EarlyView.
Comparison of therapeutic and diagnostic applications of a surface‐emitting light source with multiwavelength emission characteristics. Abstract Conventional light‐emitting‐diode‐based light sources suffer from rigidity, localized heating, and poor adaptability to skin deformation, limiting their use in skin‐attached medical devices.
In Ho Kim, Young Woo Kim, Jae‐Young Jeong, Ye Ji Shin, Chaeyeong Lee, Jae Gyun Choi, Oh Kwan Kwon, Kyoung Hwa Kim, Sang Jik Kwon, Eou‐Sik Cho, Yongmin Jeon   +10 more
wiley   +1 more source