Results 31 to 40 of about 101,746 (297)

The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

Pharmaceuticals, 2021
GPR18 is an orphan GPCR that is activated by the cannabinoid tetrahydrocannabinol (THC). Emerging evidence indicates its involvement in the control of cardiovascular functions, including heart rate, contractility, vascular tone, as well as blood pressure.
Magdalena Kotańska, Monika Kubacka, Marek Bednarski, Noemi Nicosia, Małgorzata Szafarz, Wojciech Jawień, Christa E. Müller, Katarzyna Kieć-Kononowicz   +7 more
doaj   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Erythroid anion transport, nitric oxide, and blood pressure

Frontiers in Physiology
Glycophorin A and glycophorin B are structural membrane glycoproteins bound in the band 3 multiprotein complexes on human red blood cells (RBCs). Band 3 is an erythroid-specific anion exchanger (AE1).
Kate Hsu, Kate Hsu, Kate Hsu
doaj   +1 more source

Ethyl Acetate Fraction and Isolated Phenolics Derivatives from Mandevilla moricandiana Identified by UHPLC-DAD-ESI-MSⁿ with Pharmacological Potential for the Improvement of Obesity-Induced Endothelial Dysfunction

Pharmaceutics, 2021
Endothelial dysfunction in obesity plays a key role in the development of cardiovascular diseases, and it is characterized by increased vascular tonus and oxidative stress. Thus, this study aimed to investigate the vasodilatory and antioxidant activities
Leticia L. D. M. Ferreira, Valéria de F. Leão, Cinthya M. de Melo, Thelma de B. Machado, Ana Claudia F. Amaral, Leandro L. da Silva, Naomi K. Simas, Michelle F. Muzitano, Ivana C. R. Leal, Juliana M. Raimundo   +9 more
doaj   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, EarlyView.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Vasomotor assessment by camera-based photoplethysmography

Current Directions in Biomedical Engineering, 2016
Camera-based photoplethysmography (cbPPG) is a novel technique that allows the contactless acquisition of cardio-respiratory signals. Previous works on cbPPG most often focused on heart rate extraction.
Trumpp Alexander, Schell Joachim, Malberg Hagen, Zaunseder Sebastian   +3 more
doaj   +1 more source

Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors

Biology, 2021
Cardiovascular diseases include all types of disorders related to the heart or blood vessels. High blood pressure is an important risk factor for cardiac complications and pathological disorders.
Gabriela Maria da Silva, Mirelly Cunha da Silva, Déborah Victória Gomes Nascimento, Ellen Mayara Lima Silva, Fabíola Furtado Fialho Gouvêa, Luiz Gonzaga de França Lopes, Alice Valença Araújo, Kelli Nogueira Ferraz Pereira, Thyago Moreira de Queiroz   +8 more
doaj   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

The New Nitric Oxide Donor, FOR 911B, Induces Relaxation in Isolated Rat Aorta Involving the NO/sGC/cGMP Pathway and K⁺ Channels

Receptors
Background: Nitric oxide (NO) is a gaseous molecule considered to be a protagonist in the dilation of blood vessels, and its property and/or bioavailability are reduced in pathophysiological conditions such as cardiovascular diseases.
Mirelly Cunha da Silva, Florêncio Sousa Gouveia Júnior, Thyago Moreira de Queiroz   +2 more
doaj   +1 more source

A Novel Self‐Regulated, Non‐Directional Magnetic Thermos‐Brachytherapy 125I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape

Advanced Science, EarlyView.
This work constructs magnetic nanoparticles (MNPs) and incorporates them with silver rods coated with 125I to form a novel composite seed, which exhibits direction‐independent and self‐regulated heating efficiency, as well as the capacity of preventing MNPs leakage and enabling repeated hyperthermia.
Bin Xu, Ye‐Ming Wu, Yi‐Fei Cheng, Lei Dong, Shuai‐Wen Ding, Sheng‐Rong Chen, Bin‐Da Chen, Ren‐Peng Yang, Wei‐Hua Zhang, Ya‐Jie Wang, Wei‐Pu Mao, Fan Shi, Zhi‐Cheng Jin, Jian‐Jian Chen, En‐Qi Qiao, Yu‐Qing Wang, Jin‐Ze Li, Peng Zeng, Cheng‐Wei Wu, Wei Zhang, Jin‐Bing Xie, Jian Lu, Gao‐Jun Teng   +22 more
wiley   +1 more source