Results 21 to 30 of about 118,264 (311)

Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation

Frontiers in Physiology, 2020
Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure.
Asim B. Dey, Sherif Khedr, Sherif Khedr, James Bean, Leah L. Porras, Tamika D. Meredith, Francis S. Willard, Joseph V. Hass, Xin Zhou, Maia Terashvili, Cynthia D. Jesudason, Kevin M. Ruley, Michael R. Wiley, Mark Kowala, Simon J. Atkinson, Alexander Staruschenko, Alexander Staruschenko, Mark D. Rekhter   +17 more
doaj   +1 more source

Efficacy and safety of oral pulmonary vasodilators in pulmonary veno‐occlusive disease

Pulmonary Circulation, 2022
Pulmonary veno‐occlusive disease (PVOD) or pulmonary capillary hemangiomatosis (PCH) is a rare subtype of pulmonary hypertension with dismal prognosis.
Junichi Nakamura, Ichizo Tsujino, Hideki Shima, Toshitaka Nakaya, Ayako Sugimoto, Takahiro Sato, Taku Watanabe, Hiroshi Ohira, Masaru Suzuki, Satonori Tsuneta, Ryo Hisada, Masaru Kato, Satoshi Konno   +12 more
doaj   +1 more source

Safranal Induces Vasorelaxation by Inhibiting Ca²⁺ Influx and Na⁺/Ca²⁺ Exchanger in Isolated Rat Aortic Rings

Molecules, 2022
Introduction: Safranal, which endows saffron its unique aroma, causes vasodilatation and has a hypotensive effect in animal studies, but the mechanisms of these effects are unknown.
Noor Nadhim Al-Saigh, Shtaywy Abdalla
doaj   +1 more source

Comparative Study of Different H₂S Donors as Vasodilators and Attenuators of Superoxide-Induced Endothelial Damage

Antioxidants, 2023
In the last years, research proofs have confirmed that hydrogen sulfide (H2S) plays an important role in various physio-pathological processes, such as oxidation, inflammation, neurophysiology, and cardiovascular protection; in particular, the protective
Elisabetta Marini, Barbara Rolando, Federica Sodano, Federica Blua, Giulia Concina, Stefano Guglielmo, Loretta Lazzarato, Konstantin Chegaev   +7 more
doaj   +1 more source

Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Frontiers in Cardiovascular Medicine, 2022
Stimulating collateral arteriogenesis is an attractive therapeutic target for peripheral artery disease (PAD). However, the potency of arteriogenesis-stimulation in animal models has not been matched with efficacy in clinical trials.
Alexander Silva, Christopher J. Hatch, Megan T. Chu, Trevor R. Cardinal   +3 more
doaj   +1 more source

Cerebral Vasodilators

Japanese Journal of Pharmacology, 1998
The vascular tone, vascular resistance and blood flow in the brain are regulated by neural and humoral factors in quite a different way from those of peripheral organs and tissues. In contrast to the dominant vasoconstrictor control in the periphery, the intracranial vascular tone is predominantly influenced by vasodilator mediators over ...
Toda, Noboru, Okamura, Tomio
openaire   +3 more sources

The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

Frontiers in Molecular Neuroscience, 2023
IntroductionThe disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP).
Yanna Tian, Katie Anne Fopiano, Vadym Buncha, Liwei Lang, Hayden A. Suggs, Rongrong Wang, R. Daniel Rudic, Jessica A. Filosa, Zsolt Bagi   +8 more
doaj   +1 more source

Impaired vasodilation in pregnant African Americans: Preliminary evidence of potential antecedents and consequences

, 2021
Significant health disparities exist between African Americans (AA) and European Americans (EA) in hypertension and hypertension-related disorders. Evidence suggests that this is due to impaired vasodilation in AAs.
Julian F. Thayer, Kapuku, Gaston, DeWayne P. Williams, Koenig, Julian, Lisa M. Christian, Christian, Lisa M., Williams, DeWayne P., Gaston Kapuku, Thayer, Julian F., Julian Koenig   +9 more
core   +1 more source

Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation

, 2022
Glutathione-S-transferases (GSTs) are highly promiscuous in terms of their interactions with multiple proteins, leading to various functions. In addition to their classical detoxification roles with multi-drug resistance-related protein-1 (MRP1), more ...
Russell, Tiffany M, Russell, Tiffany M., Richardson, Des R., Richardson, Des R, Tiffany M. Russell, Des R. Richardson   +5 more
core   +1 more source

Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility [PDF]

, 2005
Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular ( RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility.
Thein, E., Kisch-Wedel, H., Kemming, G., Bruhn, S., Meisner, F., Meisner, D., Kreyling, W., Zwissler, B., Flondor, M., Kreyling, W.G., Zwissler, Bernhard, Hofstetter, C., Kemming, Gregor   +12 more
core   +1 more source