Results 151 to 160 of about 53,380 (285)

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang   +5 more
wiley   +1 more source

CSE‐Derived Hydrogen Sulfide Safeguards Vascular Iron Homeostasis by Coupling Ferritin Buffering to Vasoprotection

open access: yesThe FASEB Journal, Volume 39, Issue 20, 31 October 2025.
With iron overload, wild‐type (CSE+/+) mice upregulate their CSE and ferritin expression, limiting oxidative stress and maintaining vascular health. In contrast, CSE‐deficient (CSE−/−) mice fail to induce ferritin, leading to elevated oxidative stress, vascular remodeling, and hypertension.
Hassan Mustafa Arif   +3 more
wiley   +1 more source

Choose Your Level Wisely: Assessing Density Functionals and Dispersion Corrections for Metal Carbonyl Compounds

open access: yesJournal of Computational Chemistry, Volume 46, Issue 27, 15 October 2025.
Evaluation of 54 functional/dispersion approaches for Mn(I) and Re(I) carbonyls shows that meta‐GGA and hybrid meta‐GGA functionals, particularly TPSSh(D3zero) and r2SCAN(D3BJ/D4), achieve the best balance of accuracy and efficiency, reproducing geometries, CO stretching frequencies, and energetics consistent with DLPNO‐CCSD(T).
Vinícius Glitz   +4 more
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

open access: yesArthritis Care &Research, Volume 77, Issue 10, Page 1167-1174, October 2025.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry   +2 more
wiley   +1 more source

The Effectiveness of Intravenous Magnesium Sulfate for Deliberate Hypotension in Rhinoplasty

open access: yesArchives of Anesthesia and Critical Care, 2015
Background: Deliberate hypotension is a strategy that reduces intraoperative bleeding and increases the speed of surgery in otolaryngology procedures. Magnesium (Mg) sulfate is a vasodilator agent that reduces intraoperative hypnotic requirements and in ...
Seyed Mohammad Mireskandari   +9 more
doaj  

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

open access: yesAdvanced Biology, Volume 9, Issue 10, October 2025.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez   +3 more
wiley   +1 more source

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