Results 31 to 40 of about 26,374 (207)

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

open access: yesAdvanced Science, EarlyView.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang   +15 more
wiley   +1 more source

Effects of losartan on vasomotor function and canonical transient receptor potential channels in the aortas of sinoaortic denervation rats

open access: yesClinical and Experimental Hypertension, 2018
Increased short-term blood pressure variability (BPV) is strongly correlated with target organ damage. However, the molecular mechanisms underlying abnormal BPV-induced organ damage and effective therapeutic targets are poorly understood.
Minlie Liang   +4 more
doaj   +1 more source

Randomized Sham-Controlled Pilot Study of Neurocardiac Function in Patients With Acute Ischaemic Stroke Undergoing Heart Rate Variability Biofeedback

open access: yesFrontiers in Neurology, 2021
Background: Neurocardiac dysfunction worsens clinical outcome and increases mortality in stroke survivors. We hypothesized that heart rate variability (HRV) biofeedback improves neurocardiac function by modulating autonomic nervous system activity after ...
Timo Siepmann   +10 more
doaj   +1 more source

Effects of systemic ethanol on medullary vasomotor neurons and baroreflexes

open access: yesNeuroscience Letters, 1992
The acute effects of systemic ethanol on reticulospinal sympathoexcitatory neurons were examined in vivo in anesthetized, paralyzed rats. Ethanol (0.45 g/kg, i.v.) potentiated the depressant effect of locally applied gamma-aminobutyric acid (GABA) but attenuated the excitatory effect of L-glutamate.
M K, Sun, D J, Reis
openaire   +2 more sources

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen   +11 more
wiley   +1 more source

Slow gait speed – an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus

open access: yesFrontiers in Aging Neuroscience, 2014
Objective: Gait speed is an important predictor of health that is negatively affected by aging and type 2 diabetes. Diabetes has been linked to reduced vasoreactivity, i.e. the capacity to regulate cerebral blood flow in response to CO2 challenges.
Azizah J Jor'dan   +3 more
doaj   +1 more source

Abnormal Vasomotor System Function in Idiopathic Generalized Epileptic Patients

open access: yesTürk Nöroloi Dergisi, 2014
OBJECTIVE: Autonomic dysfunction is widely recognized in both partial and generalized epilepsies. The aim of this study was to evaluate the vasomotor response in patients with generalized idiopathic epilepsy by the clinical autonomic function tests. METHODS: 124 consecutive subjects including 62 idiopathic generalized epileptic patients diagnosed for ...
Mehdi Maghbooli   +3 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang   +7 more
wiley   +1 more source

Types of Pain in Multiple System Atrophy

open access: yesMovement Disorders, EarlyView.
Abstract Background Pain affects up to 87% of people with multiple system atrophy (MSA), but it remains unclear which types of pain contribute most to the overall burden. Objective To estimate the frequency of different types of pain in MSA individuals.
Nicole Campese   +19 more
wiley   +1 more source

Respiration Can Trigger Cerebrovascular Reactivity: A Novel Method to Quantify Cerebrovascular Resistance Dynamics Using Real‐Time Phase‐Contrast MRI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To directly quantify respiration‐driven cerebrovascular resistance dynamics (CRD) using a gas‐free MRI framework based on the internal‐to‐external artery carotid flow ratio (ratio_Q). Theory and Methods Two independent datasets (n = 10 and n = 17) were used to evaluate repeatability and to compare breathing conditions.
Pan Liu   +5 more
wiley   +1 more source

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