The Biology of Vasopressin [PDF]
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response. Vasopressin synthesis
Samantha Sparapani+72 more
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Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Dayanithi, G.+4 more
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Vasopressin Prolongs Behavioral and Cardiac Responses to Mild Stress in Young But Not in Aged Rats [PDF]
In young male Wistar rats sudden silence superimposed on low intensity background noise evokes a relative decrease in heart rate. This bradycardia is accompanied by immobility behavior.
Bohus, B.,+4 more
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Vasopressin attenuates ischemia-reperfusion injury via reduction of oxidative stress and inhibition of mitochondrial permeability transition pore opening in rat hearts [PDF]
Aim of this study was to investigate the involvement of the mitochondrial permeability transition pore (MPTP) and oxidative stress in the cardioprotective effect of vasopressin (AVP) on ischemia/reperfusion (I/R) injury.
Azizi, Y.+7 more
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Antidiuretic hormone liberated the vertebrates from their aqueous environment, and permitted them to establish themselves on dry land. The combination of sensitive volume and osmoreceptors, a pituitary secretory apparatus which can vary its output from virtually zero to high levels in a short space of time, and receptor cells functioning in the ...
Hays, Richard M., Levine, Sherman D.
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Skeletal muscle: a significant novel neurohypophyseal hormone-secreting organ [PDF]
Vasopressin (arg8-vasopressin) and oxytocin are closely relalated hormones, synthesized as pre-hormones in the magnocellular neurons of the paraventricular Q6 and supraoptic nuclei of the hypothalamus.
Dario Coletti+6 more
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Vasopressin and Vasopressin Receptor Antagonists [PDF]
Vasopressin, a neurohypophyseal peptide hormone, is the endogenous agonist at V1a, V1b, and V2 receptors. The most important physiological function of vasopressin is the maintenance of water homeostasis through interaction with V2 receptors in the kidney.
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Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock. The VANISH Randomized Clinical Trial [PDF]
IMPORTANCE: Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative.
Andrews, P+102 more
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Plasma arginine vasopressin concentrations in epileptics under monotherapy [PDF]
Plasma arginine vasopressin concentrations were determined by radio-immunoassay in 112 adult epileptics who were taking carbamazepine, phenytoin, primidone, or sodium valproate in long-term monotherapy, and in 19 controls.
E Perucca+15 more
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The osmoregulation of vasopressin
The concept that secretion of the antidiuretic hormone, arginine vasopressin, is regulated by the osmolality of body water originated with the pioneering studies of Verney over 25 years ago [1]. In a classical series of experiments, this investigator showed that the injection of hypertonic saline into the carotid artery of conscious, hydrated dogs ...
Ronald L. Shelton+2 more
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