Results 111 to 120 of about 53,940 (250)

Milrinone and levosimendan improve microvascular perfusion in septic rats: a randomized, placebo-controlled trial. [PDF]

open access: yesIntensive Care Med Exp
Marcus C   +12 more
europepmc   +1 more source

Update on cellular expression and function of ANO1 channels in urethral smooth muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Activation of ANO1 channels and resulting Cl− efflux are suggested to modulate urethral smooth muscle contractility by enhancing Ca2+ influx via voltage‐dependent Ca2+ entry and resulting contraction in urethral smooth muscle cells.
Bernard T. Drumm, Neha Gupta
wiley   +1 more source

Comparison of vasopressin-first weaning versus norepinephrine-first weaning in critically ill patients. [PDF]

open access: yesInt J Clin Pharmacol Ther
Alshreef M   +8 more
europepmc   +1 more source

Mechanisms of haemoglobin mass expansion following heat stress

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Theorised mechanisms of heat stress‐induced erythropoiesis which may facilitate the expansion of haemoglobin mass. A, acute: heat stress‐induced renal ischaemia. Redistribution of blood flow away from the kidneys to facilitate thermoregulation during heat stress could reduce renal oxygen delivery, subsequently lowering renal PO2${
Elliott J. Jenkins   +4 more
wiley   +1 more source

Robust activity‐dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In cortical layer (L)5 pyramidal neurons we found that mitochondria in the axon initial segment (AIS) are distributed non‐uniformly and display robust calcium (Ca2+) uptake during action potential (AP) firing. Because the AIS is the site for the initiation of APs, which are shaped by cytosolic Ca2+ levels, we hypothesized that ...
Koen Kole, Maarten H.P. Kole
wiley   +1 more source

Inter‐Individual Differences in T1, T2, and Proton Density Using Quantitative Synthetic Imaging for 1H‐MRS Quantification

open access: yesMagnetic Resonance in Medicine, Volume 95, Issue 5, Page 2489-2499, May 2026.
ABSTRACT Purpose Metabolite concentrations can be determined from proton magnetic resonance spectroscopy (1H‐MRS) data using water as an internal reference. This calculation requires tissue‐specific water T1 and T2 relaxation constants and proton density (PD).
Samantha A. Leech   +4 more
wiley   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi   +6 more
wiley   +1 more source

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