Results 111 to 120 of about 115,344 (347)

Sustainable One‐Pot Electrochemical Approach for Entrapment of Multi‐Enzymes and Biocompatible Redox Mediator

open access: yesChemPlusChem, EarlyView.
Novel enzyme‐modified carbon felt electrodes are constructed for efficient bio‐electrocatalysis. Simultaneous electrodeposition of pyrrole and neutral red provides a facile one‐step approach for enzyme immobilization. The biocompatible conductive polymer matrix performs for the entrapment of dehydrogenase enzymes on the electrode and ensures sufficient
Hathaichanok Seelajaroen   +6 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund   +5 more
wiley   +1 more source

The inhibition of MDM2 slows cell proliferation and activates apoptosis in ADPKD cell lines

open access: yesBiology of the Cell, Volume 115, Issue 1, January 2023., 2023
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a pathology characterised by the formation of kidney cists that impair renal function. The wall of renal cysts is covered with cystic cells that show increased activation of mTOR. Abnormal mTOR activation inhibits autophagy, promotes the degradation of TP53 by the proteasome in a mechanism ...
Simone Patergnani   +5 more
wiley   +1 more source

Proteome-wide measurement of protein half-lives and translation rates in vasopressin-sensitive collecting duct cells.

open access: yesJournal of the American Society of Nephrology, 2013
Vasopressin regulates water excretion, in part, by controlling the abundances of the water channel aquaporin-2 (AQP2) protein and regulatory proteins in the renal collecting duct.
P. Sandoval   +5 more
semanticscholar   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi   +6 more
wiley   +1 more source

Gαq signalling from endosomes: A new conundrum

open access: yesBritish Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Physiology of invertebrate oxytocin and vasopressin neuropeptides

open access: yesExperimental Physiology, 2013
•  What is the topic of this review? This article describes the discovery and function of invertebrate oxytocin and vasopressin neuropeptides. •  What advances does it highlight?
Christian W. Gruber
semanticscholar   +1 more source

Gene regulation of vasopressin and vasopressin receptors in cancer

open access: yesExperimental Physiology, 2000
It is proposed that neuropeptide production by tumours is an important part of a special process of oncogenic transformation rather than a pre‐existing condition of progenitor cells; this concept is called Selective Tumour gene Expression of Peptides essential for Survival (STEPS).
openaire   +3 more sources

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

open access: yesDrug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis   +2 more
wiley   +1 more source

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