Results 171 to 180 of about 58,394 (261)

Cancer and Hypertension: Shared Mechanisms, Treatment Interactions, and Clinical Management

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer and hypertension (HTN) frequently coexist, and their relationship is increasingly recognized as a clinically relevant intersection between oncology and cardiovascular medicine. However, the extent to which this association reflects shared risk factors, common biological mechanisms, or treatment‐related effects remains incompletely ...
Peizhi Jia   +5 more
wiley   +1 more source

Multi‐Omics and Computational Pharmacology Approach With Experimental Validation Reveals the Antiproliferative Activity of Sophoricoside Against Pancreatic Cancer

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated pipeline combining network pharmacology, machine learning, and multi‑omics reveals that sophoricoside suppresses pancreatic cancer cell proliferation through PTPN1, a downstream effector. Elevated PTPN1 correlates with poor prognosis and immune infiltration, positioning it as a promising therapeutic node and prognostic biomarker for this ...
Peng Lin, Wei Cheng, Xin Qi, Jing Li
wiley   +1 more source

Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard‐Dose ACTH Response: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In patients with a remote history of traumatic brain injury, central adrenal insufficiency may remain unrecognized for decades. An apparently adequate response to standard‐dose ACTH stimulation should not preclude further evaluation of the hypothalamic–pituitary–adrenal axis when clinical and biochemical findings continue to suggest adrenal ...
Kazunori Kageyama   +5 more
wiley   +1 more source

Ethylene Glycol Poisoning Without Fomepizole in a Regional Australian Intensive Care Unit: The Lactate Gap as the Diagnostic Key and the Consequences of Nasogastric Ethanol Therapy

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT A 62‐year‐old man presented comatose with pH 6.88 and no ingestion history. A point‐of‐care lactate above 31 mmol/L with a laboratory lactate of 0.8 mmol/L revealed a lactate gap, diagnosing ethylene glycol poisoning despite a near‐normal osmolar gap. High‐dose continuous renal replacement therapy corrected the acidosis; he survived.
Jacob Athans, Prashant Maan
wiley   +1 more source

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