Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
Severe Cerebral Salt Wasting Complicating Arginine Vasopressin Deficiency After Traumatic Brain Injury. [PDF]
Saw SH +3 more
europepmc +1 more source
Intrinsic conformational equilibria position arrestin‐2 for activation
Abstract Arrestins regulate G protein‐coupled receptor (GPCR) signaling by undergoing large‐scale conformational rearrangements, yet the solution‐state equilibria that underlie arrestin pre‐activation remain poorly defined. While prior studies identified slow conformational exchange at the interdomain interface, these minor states could not be ...
Tucker J. Shriver +6 more
wiley +1 more source
Reply to Lago, T.R.; Bolognani, F. Comment on "Nazarloo et al. Oxytocin, Vasopressin and Stress: A Hormetic Perspective. <i>Curr. Issues Mol. Biol.</i> 2025, <i>47</i>, 632". [PDF]
Nazarloo HP +8 more
europepmc +1 more source
Sketching microprotein portraits
Abstract The illustrations of intricate molecular machineries inside cells created by David Goodsell continue to inspire the scientific community. Here, we aim to extend his artworks to include microproteins, a newly recognized class of small proteins with less than 100 amino acids, encoded by small open reading frames.
Gabriel Diaz +6 more
wiley +1 more source
Role of Non-catecholamines Vasopressors in the Management of Vasoplegic Syndrome after Cardiopulmonary Bypass: A Scoping Review. [PDF]
Kumar A +4 more
europepmc +1 more source
Water and wisdom: Hydration as a defence against dementia
Experimental Physiology, EarlyView.
David C. Byfield, Damian M. Bailey
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ABSTRACT Tolvaptan is widely used as an adjunct oral diuretic to loop and thiazide diuretics for the management of fluid overload in patients with congestive heart failure. Recently, tolvaptan sodium phosphate (TSP), a water‐soluble prodrug of tolvaptan, was developed for intravenous administration and has demonstrated efficacy and safety in clinical ...
Takaya Uno +10 more
wiley +1 more source
Acute pulmonary Edema following Myometrial pituitrin injection during laparoscopic myomectomy. [PDF]
Wang Z, Song S, Zhang J.
europepmc +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source

