A multiscale model of the regulation of aquaporin 2 recycling [PDF]
npj Systems Biology and Applications, 2022 The response of cells to their environment is driven by a variety of proteins and messenger molecules. In eukaryotes, their distribution and location in the cell are regulated by the vesicular transport system.
Christoph Leberecht +2 more
doaj +5 more sources
α-Actinin 4 Links Vasopressin Short-Term and Long-Term Regulation of Aquaporin-2 in Kidney Collecting Duct Cells [PDF]
Frontiers in Physiology, 2021 Water permeability of the kidney collecting ducts is regulated by the peptide hormone vasopressin. Between minutes and hours (short-term), vasopressin induces trafficking of the water channel protein aquaporin-2 to the apical plasma membrane of the ...
Cheng-Hsuan Ho +4 more
doaj +2 more sources
Neural Regulation of Urothelial Water Transport: Pelvic Nerve Stimulation Induces Aquaporin-2 and Vasopressin V1a Receptor Translocation in the Rat Urinary Bladder [PDF]
International Neurourology JournalPurpose Aquaporin-2 (AQP2) and vasopressin V1a receptor (AVP-V1a) are membrane proteins involved in water transport regulation in renal and extrarenal tissues. Their presence in the urinary bladder suggests a role in local water handling.
Seong Hyeon Yu +3 more
doaj +2 more sources
Upregulation of aquaporin-2 and caveolins in rat bladder with outlet obstruction-induced detrusor overactivity [PDF]
Investigative and Clinical UrologyPurpose: Bladder outlet obstruction (BOO) leads to detrusor overactivity (DO) and structural remodeling of the bladder. However, the molecular mechanisms underlying this process remain incompletely understood.
Seong Hyeon Yu +3 more
doaj +2 more sources
Sorting Nexin 27 Regulates the Lysosomal Degradation of Aquaporin-2 Protein in the Kidney Collecting Duct [PDF]
Cells, 2020 Sorting nexin 27 (SNX27), a PDZ (Postsynaptic density-95/Discs large/Zonula occludens 1) domain-containing protein, cooperates with a retromer complex, which regulates intracellular trafficking and the abundance of membrane proteins.
Hyo-Jung Choi +6 more
doaj +2 more sources
miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury [PDF]
Renal Failure, 2021 Objective This study was designed to uncover the mechanism of miR-34b-5p-mediated aquaporin-2 (AQP2) in sepsis-induced injury using human renal tubular epithelial cells (HK-2). Methods Serum levels of miR-34b-5p, TNF-α, IL-1β, IL-6, serum creatinine (SCr)
Caifa Zheng +3 more
doaj +2 more sources
Molecular Characterization of an Aquaporin−2 Mutation Causing Nephrogenic Diabetes Insipidus [PDF]
Frontiers in Endocrinology, 2021 The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis. AQP2 mutation leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, polydipsia, and hypernatremia.
Qian Li +10 more
doaj +2 more sources
Diabetes insipidus in mice with a mutation in aquaporin-2. [PDF]
PLoS Genetics, 2005 Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin. Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin
David J Lloyd +3 more
doaj +4 more sources
Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice
Frontiers in Cell and Developmental Biology, 2023 The UDP-glucose receptor P2RY14, a rhodopsin-like G protein-coupled receptor (GPCR), was previously described as receptor expressed in A-intercalated cells of the mouse kidney.
Fabian Baalmann +10 more
doaj +1 more source
Frontiers in Immunology, 2022 Microglial and astrocyte activation and related cytokine secretion play key roles in secondary brain injury following intracerebral hemorrhage (ICH). We assessed the role of aquaporin (AQP)2 in immune response after ICH.
Shuwen Deng +3 more
doaj +1 more source