Results 41 to 50 of about 41,663 (295)

Effect of Diet and Water Intake on Aquaporin 2 Function [PDF]

Childhood Kidney Diseases, 2016
Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively understood that the amount of sodium and potassium intake directly affects blood pressure and
Jun-Mo Kim, Tae-Hee Kim, Tong Wang
doaj   +1 more source

A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]

, 2017
Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core   +3 more sources

TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis [PDF]

, 2020
Renal scarring after pyelonephritis is linked to long-term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant ...
Collins, Christina A, Daugherty, Allyssa L, Hreha, Teri N, Hunstad, David A, Paluri, Nitin, Twentyman, Joy   +5 more
core   +1 more source

Alleviation of Cerebral Infarction of Rats With Middle Cerebral Artery Occlusion by Inhibition of Aquaporin 4 in the Supraoptic Nucleus

ASN Neuro, 2020
In ischemic stroke, vasopressin hypersecretion is a critical factor of cerebral swelling and brain injury. To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle ...
Dan Cui, Shuwei Jia, Jiawei Yu, Dongyang Li, Tong Li, Yang Liu, Jinlong Chang, Xiaoran Wang, Xiaoyu Liu, Yu-Feng Wang   +9 more
doaj   +1 more source

Quantitative analysis of aquaporin-2 phosphorylation

American Journal of Physiology-Renal Physiology, 2010
The action of vasopressin in rodent collecting ducts to regulate water permeability depends in part on increases in phosphorylation of the water channel aquaporin-2 (AQP2) at three sites: Ser256, Ser264, and Ser269. Previous studies of AQP2 phosphorylation have depended largely on qualitative data using protein mass spectrometry and phospho-specific ...
Xie, Luke, Hoffert, Jason D, Chou, Chung-Lin, Yu, Ming-Jiun, Pisitkun, Trairak, Knepper, Mark A, Fenton, Robert A.; id_orcid 0000-0003-1623-199X   +6 more
openaire   +3 more sources

Upregulation of aquaporin-2 and caveolins in rat bladder with outlet obstruction-induced detrusor overactivity [PDF]

Investigative and Clinical Urology
Purpose: Bladder outlet obstruction (BOO) leads to detrusor overactivity (DO) and structural remodeling of the bladder. However, the molecular mechanisms underlying this process remain incompletely understood.
Seong Hyeon Yu, Ho Seok Chung, Do Gyeong Lim, Sun-Ouck Kim   +3 more
doaj   +1 more source

Consequences of aquaporin 2 tetramerization for genetics and routing [PDF]

Nephrology Dialysis Transplantation, 2000
in 90% of cases caused by mutations in the gene on the X chromosome coding for the V 2 receptor. In 10% blotting analysis showed that AQP2-E258K was of afflicted families, mutations in the AQP2 water retained in the Golgi compartment and not retarded channel gene have been shown to be the cause of the in the endoplasmic reticulum as are AQP2 mutants in
Kamsteeg, E.J., Mulders, S.M., Bichet, D.G., Deen, P.M.T., Os, C.H. van   +4 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Reduced urinary release of AQP1‐ and AQP2‐bearing extracellular vesicles in patients with advanced chronic kidney disease

Physiological Reports, 2021
Although several studies have shown that release of water channel proteins, aquaporin 1 (AQP1) and AQP2 in urinary extracellular vesicles (uEV‐AQP1 and ‐AQP2), were altered in experimental kidney injury models, their release in human chronic kidney ...
Sayaka Oshikawa‐Hori, Naoko Yokota‐Ikeda, Hiroko Sonoda, Yosuke Sasaki, Masahiro Ikeda   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source