Results 51 to 60 of about 41,663 (295)

Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2019
Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR)
Min Liu, Qinghua Han, Jinglu Yang
doaj   +1 more source

Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation. [PDF]

PLoS ONE, 2015
Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells.
Michael S Dicay, Christina L Hirota, Natalie J Ronaghan, Michael A Peplowski, Raza S Zaheer, Colin A Carati, Wallace K MacNaughton   +6 more
doaj   +1 more source

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system [PDF]

, 2018
Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 42 ...
Beauwens, Renaud, Blockmans, Marianne, Cheong, Siew, Devuyst, Olivier, Erneux, Christophe, Gayral, Stéphanie, Jacoby, Monique, Janas, Sylvie, Markadieu, Nicolas, Pernot, Eileen, Pouillon, Valérie, Rossier, Bernard, Schurmans, Stéphane, Terryn, Sara   +13 more
core  

Structure of Aquaporin-2 Vasopressin Water Channel [PDF]

Journal of Biological Chemistry, 1996
Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel in the kidney collecting duct. AQP-2 is selectively permeable to water molecule and is translocated between the apical membrane and subapical endosomes in response to vasopressin. To investigate the localization and structure of the aqueous pathway of the AQP-2 water channel, a series of site-
L, Bai, K, Fushimi, S, Sasaki, F, Marumo
openaire   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Duloxetine-Induced Antidiuresis in Rats with Lithium-Induced Nephrogenic Diabetes Insipidus

Life
Antidepressants, including duloxetine, are a significant cause of drug-induced hyponatremia, which can disrupt the continuation of medication. Tolvaptan is beneficial for correcting hyponatremia caused by the syndrome of inappropriate antidiuresis, but ...
Sua Kim, Chor Ho Jo, Gheun-Ho Kim
doaj   +1 more source

Epitheliale und endotheliale Effekte der Caveolin-1-Deletion in der Niere [PDF]

, 2019
Caveolen, cholesterin- und glycosphingolipidhaltige Einstülpungen der Plasmamembran, sind an wichtigen zellulären Leistungen wie der Endozytose und Signaltransduktion beteiligt.
Willière, Yan
core   +1 more source

Trafficking mechanism of water channel aquaporin‐2 [PDF]

Biology of the Cell, 2005
Targeted positioning of the water channel AQP2 (aquaporin‐2) strictly regulates body water homoeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. In addition to the cAMP‐mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signalling cascades can also ...
Yumi, Noda, Sei, Sasaki
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Aquaporin-2 membrane targeting: still a conundrum [PDF]

American Journal of Physiology-Renal Physiology, 2017
The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis.
Olesen, Emma Tina Bisgaard, Fenton, Robert A.   +1 more
openaire   +5 more sources