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Journal of the American Society of Nephrology, 2012 Aquaporin 2 (AQP2) is widely recognized for its role in vasopressin-stimulated water transport across the collecting duct and hence in the production of concentrated urine.[1][1],[2][2] AQP2 is primarily expressed in the apical plasma membrane and subapical vesicles of the collecting duct ...
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Aquaporin-10 represents an alternative pathway for glycerol efflux from human adipocytes. [PDF]
PLoS ONE, 2013 BACKGROUND: Glycerol outflow from adipocytes has been considered for a decade to be mediated by aquaporin-7, an aquaglyceroporin highly expressed in the adipose tissue. Its involvement in glycerol metabolism has been widely studied also in humans. Recent
Umberto Laforenza +2 more
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Expression and prognostic value of aquaporin 1, 3 in cervical carcinoma in women of Uygur ethnicity from Xinjiang, China. [PDF]
PLoS ONE, 2014 BACKGROUND: Overexpression of several aquaporins has been reported in different types of human cancer but the role of aquaporins in carcinogenesis has not yet been clearly defined.
Rui Chen +4 more
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Viruses, 2021 Vascular changes represent a characteristic feature of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leading to a breakdown of the vascular barrier and subsequent edema formation.
Lisa Allnoch +12 more
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Localization and trafficking of aquaporin 2 in the kidney [PDF]
Histochemistry and Cell Biology, 2008 Aquaporins (AQPs) are membrane proteins serving in the transfer of water and small solutes across cellular membranes. AQPs play a variety of roles in the body such as urine formation, prevention from dehydration in covering epithelia, water handling in the blood-brain barrier, secretion, conditioning of the sensory system, cell motility and metastasis,
Takata, Kuniaki +4 more
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FEBS Open Bio, 2015 Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in ...
Noreen Klein +3 more
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Aquaporin‐2 regulation in health and disease [PDF]
Veterinary Clinical Pathology, 2012 AbstractAquaporin‐2 (AQP2), the vasopressin‐regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate ...
M Judith, Radin +7 more
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Aquaporin-4 expression in distal myopathy with rimmed vacuoles
BMC Neurology, 2012 Background Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy is clinically characterized by the early involvement of distal leg muscles. The striking pathological features of the myopathy are muscle fibers with rimmed vacuoles.
Hoshi Akihiko +5 more
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Aquaporin-2 in the immature rat [PDF]
Journal of the American Society of Nephrology, 1997 The immature kidney is resistant to arginine vasopressin. To define the role of aquaporin-2 (AQP-2), the developmental expression of this water channel was studied in rats. AQP-2 levels were lower during early postnatal life, reaching maximal expression at 10 wk of age. Concurrently, urine osmolality increased from 242 +/- 60 to 1267 +/- 311 mosmol/kg.
M, Bonilla-Felix, W, Jiang
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Frontiers in Physiology, 2019 Aquaporin-2 (AQP2) is a molecular water channel protein responsible for water reabsorption by the kidney collecting ducts. Many water balance disorders are associated with defects in AQP2 gene expression regulated by the peptide hormone vasopressin. Here,
Shu-Ting Lin +10 more
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