Results 1 to 10 of about 34,897 (281)

Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor [PDF]

Journal of Advanced Research
Introduction: Nuclear receptor corepressor 1(NCOR1) is reported to play crucial roles in cardiovascular diseases, but its function in the kidney has remained obscure. Objective: We aim to elucidate the role of collecting duct NCOR1 in blood pressure (BP)
Da Shang, Lin-Juan Du, Chuan-Ming Hao
exaly   +6 more sources

Claudins in the Renal Collecting Duct [PDF]

International Journal of Molecular Sciences, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the
Janna Leiz, Kai M. Schmidt-Ott
core   +11 more sources

Modus operandi of ClC-K2 Cl⁻ Channel in the Collecting Duct Intercalated Cells [PDF]

Biomolecules, 2023
The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure.
Anna Stavniichuk, Kyrylo Pyrshev, Viktor N. Tomilin, Mariya Kordysh, Oleg Zaika, Oleh Pochynyuk   +5 more
doaj   +2 more sources

A complete response to Pembrolizumab for metastatic collecting duct carcinoma of the kidney [PDF]

Urology Case Reports
Collecting duct carcinoma, also known as Bellini duct cancer, is a rare subtype of renal cell carcinoma with a poor prognosis in the metastatic setting.
Satoki Abe, Toru Inoue, Shinro Hata, Tadamasa Shibuya, Tadasuke Ando, Toshitaka Shin   +5 more
doaj   +2 more sources

A rare case of collecting duct renal cell carcinoma [PDF]

Urology Case Reports
Collecting duct carcinoma is an exceptionally rare and aggressive form of renal cell carcinoma (RCC), representing between 0.4 and 1.8% of RCC cases. The most commonly affected demographic are young African-American males. Here, we present a rare case of
Vance Gentry, Sriharsha Talluri, Richard Hessler, Benjamin Waldorf   +3 more
doaj   +2 more sources

Clear cell renal cell carcinoma with collecting duct carcinoma transformation: a case report and review of the literature [PDF]

BMC Urology
Collecting duct carcinoma (CDC), a rare and aggressive renal malignancy originating from the medullary collecting ducts, often presents with nonspecific symptoms and rapid metastatic progression, yielding a dismal prognosis. The occurrence of a composite
Mingwei Liang, Luona Li, Yalei Cao, Keqin Zhang, Qiang Fu   +4 more
doaj   +2 more sources

A case of an advanced renal collecting duct carcinoma in which initial therapeutic effect was achieved with pembrolizumab plus axitinib [PDF]

IJU Case Reports
Introduction Renal collecting duct carcinoma is often found in advanced cancers and has a poor prognosis. Here, we present the case of symptomatic metastatic collecting duct carcinoma in which we observed an initial therapeutic effect of immune ...
Yuichiro Atagi, Kei Daizumoto, Shinsuke Mohri, Kai Somiya, Daisuke Seto, Shigeo Nakanishi, Yutaka Yanagihara, Iku Ninomiya, Kenjiro Okamoto, Sadamu Yamashi   +9 more
doaj   +2 more sources

Thick Ascending Limb Specific Inactivation of Myh9 and Myh10 Myosin Motors Results in Progressive Kidney Disease and Drives Sex-specific Cellular Adaptation in the Distal Nephron and Collecting Duct [PDF]

Function
Our previous work established a role for myosin motor proteins MYH9 and MYH10 in trafficking of thick ascending limb (TAL) cargoes uromodulin and Na+-K+-2Cl- cotransporter NKCC2.
Karla L Otterpohl, Brook W Busselman, Jenna L Zimmerman, Malini Mukherjee, Claire Evans, Kelly Graber, Vedant P Thakkar, Jermaine G Johnston, Arooba Ilyas, Michelle L Gumz, Douglas C Eaton, Jeff M Sands, Kameswaran Surendran, Indra Chandrasekar   +13 more
doaj   +2 more sources

Bellini Duct Carcinoma: A Rare Entity [PDF]

Journal of Clinical and Diagnostic Research, 2016
Bellini duct carcinoma of kidney derives from collecting duct and is associated with an aggressive course and extremely poor prognosis. Here, we report an interesting case of Collecting Duct Carcinoma (CDC) with Inferior Vena Cava (IVC) thrombus and ...
Amit Kumar Mishra, Ramanitharan Manikandan, Lalgudi Narayan Dorairajan, Jayesh Kumar Mittal, Jinkala Sree Rekha   +4 more
doaj   +1 more source

Differentiated mouse kidney tubuloids as a novel in vitro model to study collecting duct physiology

Frontiers in Cell and Developmental Biology, 2023
Kidney tubuloids are cell models that are derived from human or mouse renal epithelial cells and show high similarities with their in vivo counterparts. Tubuloids grow polarized in 3D, allow for long-term expansion, and represent multiple segments of the
C. J. A. Olde Hanhof, E. Dilmen, F. A. Yousef Yengej, F. A. Yousef Yengej, F. Latta, C. M. E. Ammerlaan, C. M. E. Ammerlaan, J. Schreurs, L. Hooijmaijers, J. Jansen, J. Jansen, J. Jansen, M. B. Rookmaaker, I. Orhon, M. C. Verhaar, J. G. Hoenderop   +15 more
doaj   +1 more source