Results 51 to 60 of about 65,263 (290)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Terlipressin or norepinephrine in septic shock: do we have the answer? [PDF]

, 2019
Comment on Terlipressin versus norepinephrine as infusion in patients with septic shock: a multicentre, randomised, double-blinded trial.
Russell, James A., Williams, Mark D.
core   +1 more source

Prevention and Management of Percutaneous Coronary Intervention‐Related Complications: Assessing the Impact of Simulation‐Based Learning and Human Factors Training

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Complications of percutaneous coronary intervention (PCI) remain infrequent but are associated with a risk of serious injury or death. The techniques and devices required to manage them may be unfamiliar or unavailable to operators.
Junichi Fukamizu, Tobias MacCarthy, Ikuo Shimizu, Shigeki Ariura, Ryouta Tanetani, Shouta Arahira, Manabu Tamura, Ken Masamune, Kalaivani Mahadevan, Nitin Chandramohan, Thomas Hovasse, Jacques Monsegu, James Nolan, Joelle Kefer, Piotr Musialek, Martin Oberhoff, Michael Haude, Hakim Benamer, Olivier Muller, Patrick A. Calvert, Satoru Sumitsuji, Peter O'Kane, Gabor Toth, Thomas Cuisset, William Wijns, Thomas W. Johnson   +25 more
wiley   +1 more source

Using Shock Index as a Predictor of ICU Readmission: A Quality Iimprovement Project [PDF]

, 2015
Background: Adverse events will occur in one-third of patients discharged from the intensivecare unit (ICU) and evidence shows that ICU readmissions increase a patient’s length of stay,mortality, hospital costs, and nosocomial infections, as well as ...
Sykes, Melissa
core   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. [PDF]

, 2018
BackgroundComplications after injury, such as acute respiratory distress syndrome (ARDS), are common after traumatic brain injury (TBI) and associated with poor clinical outcomes.
Calfee, Carolyn S, Cohen, Mitchell J, Conroy, Amanda S, Gibb, Stuart L, Hendrickson, Carolyn M, Keating, Sheila M, Miyazawa, Byron Y, Pati, Shibani, Ross, Erin   +8 more
core  

Cardiogenic shock mortality according to Aetiology in a Mediterranean cohort: Results from the Shock‐CAT study

ESC Heart Failure, Volume 12, Issue 2, Page 1336-1345, April 2025.
Abstract Aims Mortality in cardiogenic shock (CS) remains elevated, with the potential for CS causes to impact prognosis and risk stratification. The aim was to investigate in‐hospital prognosis and mortality in CS patients according to aetiology. We also assessed the prognostic accuracy of CardShock and IABP‐SHOCK II scores.
Cosme García‐García, Teresa López‐Sobrino, Esther Sanz‐Girgas, Maria R. Cueto, Jaime Aboal, Pablo Pastor, Irene Buera, Alessandro Sionis, Rut Andrea, Judit Rodríguez‐López, Jose Carlos Sánchez‐Salado, Carlos Tomas, Jordi Bañeras, Albert Ariza, Josep Lupón, Antoni Bayés‐Genís, Ferran Rueda, Grup de Treball de Cures Agudes Cardiològiques Societat Catalana de Cardiologia   +17 more
wiley   +1 more source

Physical outcome measure for critical care patients following intensive care discharge [PDF]

, 2016
Introduction: The aim of this study was to evaluate the most suitable physical outcome measures to be used with critical care patients following discharge. ICU survivors experience physical problems such as reduced exercise capacity and intensive care
Daniel, M, Devine, H, Kinsella, J., MacTavish, P, McPeake, J., Quasim, T.   +5 more
core   +1 more source

Vasopressors for hypotensive shock [PDF]

Cochrane Database of Systematic Reviews, 2016
Initial goal-directed resuscitation for hypotensive shock usually includes administration of intravenous fluids, followed by initiation of vasopressors. Despite obvious immediate effects of vasopressors on haemodynamics, their effect on patient-relevant outcomes remains controversial. This review was published originally in 2004 and was updated in 2011
Gunnar, Gamper, Christof, Havel, Jasmin, Arrich, Heidrun, Losert, Nathan Leon, Pace, Marcus, Müllner, Harald, Herkner   +6 more
openaire   +2 more sources

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source