Results 131 to 140 of about 37,157 (250)
CRISPR‐Cas9 and precision editing technologies enable a variant‐mechanism‐driven framework for genetic disease research and therapeutic development. Pathogenic variants are first interpreted according to mutation type, coding or regulatory consequence, tissue context, and disease mechanism.
Zijing Wen, Jianming Su
wiley +1 more source
Abstract This article presents checklists designed to guide clinicians in the comprehensive management of pregnant individuals with sickle cell disease, including prepregnancy, antepartum, delivery, and postpartum care, as well as the specific management of vaso‐occlusive crises.
Society for Maternal‐Fetal Medicine (SMFM) +7 more
wiley +1 more source
Response surface optimization identified 60% microwave power and 40 s as a balanced condition for recovering bioactive compounds from Arisaema schimperianum tuber. LC–MS/MS profiling revealed diverse metabolites, while freeze‐drying best preserved thermolabile compounds, highlighting an effective strategy for maximizing extraction efficiency and ...
Gezahegn Abawa Zeleke +2 more
wiley +1 more source
Estudo de pozolana autoclavada baseada em óxido de cálcio derivado da concha da ostra Crossostrea gigas [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência e Engenharia de MateriaisA região da grande Florianópolis é responsável por 80% da produção nacional de moluscos bivalves entre ...
Souza, Rafael Gonçalves de
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De Stupro: First Insights on Rape and Its Prosecution in Maltese Courts (1701–10)
Abstract This article constitutes a first in‐depth investigation of rape and the prosecution of this crime in early eighteenth‐century Malta. The research, which is based on sixteen rape accusations claimed at the secular courts in Malta between 1701 and 1710, has analysed cases categorized as ‘simple rape’, ‘violent rape’ and rape committed under the ...
Vanessa Buhagiar
wiley +1 more source
Estratégia computacional para projeto de vasos de pressão [PDF]
Vasos de pressão são recipientes projetados para resistir a diferenças entre a pressão interna e externa. Por serem equipamentos de grande periculosidade, sua construção deve ser regida por normas internacionalmente reconhecidas.
Nogueira, Bernardo Fonseca
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American Journal of Hematology, Volume 101, Issue 9, Page 2430-2434, September 2026.
Ferras Alashkar +10 more
wiley +1 more source
Summary Haemoglobin SC (HbSC) disease is the second most prevalent form of sickle cell disease, but evidence for hydroxyurea (hydroxycarbamide; HU) to prevent pain episodes was limited until the prospective identification of variables as outcomes for treatment (PIVOT) trial.
Alice Girard +10 more
wiley +1 more source

