Results 21 to 30 of about 141 (69)

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, Volume 41, Issue 7, Page 1740-1749, July 2026.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen, Joshua L.I. Frost, David P. Vaughan, Raquel Real, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Eleanor J. Stafford, Lesley Wu, Olaf Ansorge, Annelies Quaegebeur, Kieren S.J. Allinson, Thomas T. Warner, Zane Jaunmuktane, Anjum Misbahuddin, P. Nigel Leigh, Boyd C.P. Ghosh, Kailash P. Bhatia, Alistair Church, Christopher Kobylecki, Michele T.M. Hu, James B. Rowe, Alan A. Shomo, Danielle L. Graham, Omar S. Mabrouk, Huw R. Morris, Esther M. Sammler, Edwin Jabbari   +27 more
wiley   +1 more source

Tailoring Li‐ion Storage and Transport in Two‐Dimensional Conjugated Metal‐Organic Frameworks via Precise Nitrogen Incorporation

Advanced Functional Materials, Volume 36, Issue 51, 25 June 2026.
Two nitrogen‐doped 2D conjugated metal‐organic frameworks (2D c‐MOFs, namely Cu‐Nx‐OHBA, x = 2 or 4) are synthesized, featuring precise nitrogen incorporation via rational ligand design. The Cu‐Nx‐OHBA 2D c‐MOFs are largely tailorable by varying skeletal nitrogen density, with respect to electrical conductivity, Li‐storage capacitance, and Li‐transport
Xiangyu Li, Shaoze Shi, Fucai Cui, Rashid Iqbal, Pengyu Wang, Tianrui Wu, Jingcheng Hao, Renhao Dong   +7 more
wiley   +1 more source

Detection of Toxic Gases and Volatile Organic Compounds Using Highly Adsorptive Nanomaterials: A Comprehensive Assessment

EcoMat, Volume 8, Issue 5, May 2026.
This review highlights how nanomaterials with high adsorption capacities including carbon‐based structures, transition metal oxides, 2D layers, and zeolites enable sensitive and selective detection of toxic gases and VOCs. Their tailored properties and sensing mechanisms drive the development of next‐generation gas sensors for environmental and ...
Hamdy A. Ismail, Sabbah Ataya, Mohamed M. Goda, Ahmed G. Hussein, Ahmed Ramah, Ahmad G. Ramadan, Rashid Khan, Joy Djuansjah, Swellam W. Sharshir, Ahmed El‐Harairy   +9 more
wiley   +1 more source

Comparison of Signal‐ and Volume‐Based Ventilation‐Weighted Assessment Using 3D FLORET UTE MRI in Patients With Various Pulmonary Disease

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2814-2827, May 2026.
ABSTRACT Purpose 3D free‐breathing, proton, contrast‐agent‐free MR methods are increasingly used for pulmonary ventilation‐weighted measurements. The methods are split between: (1) signal‐based, which rely on lung parenchyma signal changes during respiration, and (2) volume‐based that utilize the Jacobian determinant of deformation fields from the ...
Filip Klimeš, Joseph W. Plummer, Andreas Voskrebenzev, Marcel Gutberlet, Marius M. Klein, Matthew M. Willmering, Alexander M. Matheson, Abdullah S. Bdaiwi, Frank Wacker, Jason C. Woods, Zackary I. Cleveland, Laura L. Walkup, Jens Vogel‐Claussen   +12 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, Volume 20, Issue 4, Page 920-932, April 2026.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Automated Cryo‐EM and Supervised Machine Learning Enable Reproducible Characterization of Extracellular Vesicles and Co‐Isolating Particles

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Automated cryo‐electron microscopy enables high‐throughput and unbiased image acquisition, which, combined with supervised machine learning allows modelling and detection of lipid membranes and other structures, like lipoproteins. This integration provides a powerful approach for analysis of EV size and morphology, as well as sample purity assessment ...
Agustin Enciso‐Martinez, Frank G. A. Faas, Anja W. M. de Jong, Ton G. van Leeuwen, Rienk Nieuwland, Edwin van der Pol, Peter ten Dijke, Roman I. Koning   +7 more
wiley   +1 more source

Micro‐Transfer Printed Continuous‐Wave and Mode‐Locked Laser Integration at 800 nm on a Silicon Nitride Platform

Laser &Photonics Reviews, Volume 20, Issue 7, 6 April 2026.
A heterogeneous III‐V/SiN platform for lasers at 800 nm is realized using the micro‐transfer printing method. Efficient GaAs gain sections are directly butt‐coupled to SiN waveguides, enabling continuous‐wave and mode‐locked extended‐cavity lasers. The mode‐locked lasers generate highly stable pulse trains with repetition rates up to 9.2 GHz and a ...
Max Kiewiet, Stijn Cuyvers, Maximilien Billet, Konstantinos Akritidis, Valeria Bonito Oliva, Gaudhaman Jeevanandam, Sandeep Saseendran, Manuel Reza, Pol Van Dorpe, Roelof Jansen, Joost Brouckaert, Günther Roelkens, Kasper Van Gasse, Bart Kuyken   +13 more
wiley   +1 more source

The evolution of fungus farming in ship‐timber beetles (Coleoptera: Lymexyloidea)

Systematic Entomology, Volume 51, Issue 2, April‐June 2026.
Micro‐computed tomography (micro‐CT) effectively detects mycetangia (fungal pouches) on ovipositors of extant lymexyloid taxa but remains inconclusive for extinct taxa due to preservation limitations. The first comprehensive molecular phylogeny of the Lymexyloidea, integrated with mycetangia data, supports a single origin of obligate fungus farming ...
Lennart J. J. van de Peppel, Veit Grabe, Maximilian Lehenberger, Frank F. M. Becker, Gerrit Holighaus, Peter H. W. Biedermann   +5 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, Volume 600, Issue 4, Page 467-480, February 2026.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Near-surface geophysical and sedimentological analyses for the lower havel inner delta - a dataset of the floodplain lithostratigraphy. [PDF]

Data Brief
Köhler A, Pohle M, Bauckholt M, Birnstengel S, Kaniecki M, Schneider B, Werban U, Zielhofer C.   +7 more
europepmc   +1 more source