Results 161 to 170 of about 25,428 (209)
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Immunogenetics, 2018
Caudal-type homeobox protein 2 (CDX-2) is an intestine-specific transcription factor (TF), with a polymorphic binding site (Cdx-2, rs11568820, A/G) in the vitamin D receptor gene (VDR). The molecular mechanism underlying Cdx-2 association with conditions like osteoporosis, which depends on intestinal VDR expression and calcium absorption, is believed ...
Vanessa Meyer, Liza Bornman
exaly +3 more sources
Caudal-type homeobox protein 2 (CDX-2) is an intestine-specific transcription factor (TF), with a polymorphic binding site (Cdx-2, rs11568820, A/G) in the vitamin D receptor gene (VDR). The molecular mechanism underlying Cdx-2 association with conditions like osteoporosis, which depends on intestinal VDR expression and calcium absorption, is believed ...
Vanessa Meyer, Liza Bornman
exaly +3 more sources
In vivo function of VDR in gene expression-VDR knock-out mice
The Journal of Steroid Biochemistry and Molecular Biology, 1999Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression. The transactivation function of VDR is activated by binding 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3], an active form of vitamin D. Conversion from 25(OH)D3 is finely regulated in kidney by 25(OH)D3 1alpha-hydroxylase[25(OH)D 1alpha ...
S, Kato +5 more
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Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex
Journal of Cellular Biochemistry, 2006AbstractOur previous study demonstrate that vitamin D3 induces the binding of vitamin D3 receptor (VDR) to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as the transcription component of the VDR/Sp1 ...
Hsuen-Tsen, Cheng +4 more
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Paget’s disease—A VDR coactivator disease? [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2004 Paget's disease is the most exaggerated example of bone remodeling with increased osteoclastic bone resorption followed by excessive bone formation. One of the earliest findings in our studies of Paget's disease is that pagetic osteoclast (OCL) precursors are hyper-responsive to 1,25-(OH)(2)D(3) and form OCL at concentrations of 1,25-(OH)(2)D(3) that ...
Kurihara, Noriyoshi +4 more
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Upregulation of VDR-associated lncRNAs in Schizophrenia
Journal of Molecular Neuroscience, 2021Vitamin D receptor (VDR) signaling has been found to contribute to the pathology of numerous neuropsychiatric diseases including schizophrenia. Notably, VDR signaling has a functional relationship with many long non-coding RNAs (lncRNAs) such as SNHG6, LINC00346 and LINC00511.
Soudeh Ghafouri-Fard +5 more
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VDR - the next generation [PDF]
, 2008 The European Maritime Data Management (EMDM) project faces the challenge of safe and secure European transport development with the study and development of new applications, functionalities and proposals for Voyage Data Recorders (VDRs) and Electronic Logbooks (ELBs).
Austin, S. +3 more
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Redefining the targets of the vitamin D receptor (VDR) utilizing a novel VDR reporter mouse
The Journal of Immunology, 2021Abstract The vitamin D receptor (VDR) is a ligand-activated nuclear protein that regulates gene transcription. Vitamin D target cells are identified by the expression of VDR. Kidney and colon epithelial cells constitutively express high levels of the VDR. Immune cells also express the VDR; however, at significantly lower levels.
Juhi Arora, Margherita T Cantorna
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Cybersecurity risk assessment of VDR
Journal of Navigation, 2023AbstractThe voyage data recorder (VDR) is a data recording system that aims to provide all navigational, positional, communicational, sensor, control and command information for data-driven investigation of accidents onboard ships. Due to the increasing dependence on interconnected networks, cybersecurity threats are one of the most severe issues and ...
Ömer Söner +3 more
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Therapeutic implications of the TLR and VDR partnership
Trends in Molecular Medicine, 2007The innate immune system provides the host with an immediate and rapid defense against invading microbes. Detection of foreign invaders is mediated by a class of receptors that are known as the pattern recognition receptors, such as the family of Toll-like receptors (TLRs).
Philip T, Liu +2 more
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Clinical calcium, 2005
Typical abnormalities of hereditary rickets type II patients were observed in the mice deficient of VDR with growth retardation, impaired bone formation and alopecia. Except alopecia, all of the abnormalities were rescued by dietary supplement of high minerals.
Shigeaki, Kato, Yamamoto, Yoko
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Typical abnormalities of hereditary rickets type II patients were observed in the mice deficient of VDR with growth retardation, impaired bone formation and alopecia. Except alopecia, all of the abnormalities were rescued by dietary supplement of high minerals.
Shigeaki, Kato, Yamamoto, Yoko
openaire +1 more source