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In vivo function of VDR in gene expression-VDR knock-out mice
The Journal of Steroid Biochemistry and Molecular Biology, 1999Vitamin D exerts many biological actions through nuclear vitamin D receptor (VDR)-mediated gene expression. The transactivation function of VDR is activated by binding 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3], an active form of vitamin D. Conversion from 25(OH)D3 is finely regulated in kidney by 25(OH)D3 1alpha-hydroxylase[25(OH)D 1alpha ...
S, Kato +5 more
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Immunogenetics, 2018
Caudal-type homeobox protein 2 (CDX-2) is an intestine-specific transcription factor (TF), with a polymorphic binding site (Cdx-2, rs11568820, A/G) in the vitamin D receptor gene (VDR). The molecular mechanism underlying Cdx-2 association with conditions like osteoporosis, which depends on intestinal VDR expression and calcium absorption, is believed ...
Vanessa, Meyer, Liza, Bornman
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Caudal-type homeobox protein 2 (CDX-2) is an intestine-specific transcription factor (TF), with a polymorphic binding site (Cdx-2, rs11568820, A/G) in the vitamin D receptor gene (VDR). The molecular mechanism underlying Cdx-2 association with conditions like osteoporosis, which depends on intestinal VDR expression and calcium absorption, is believed ...
Vanessa, Meyer, Liza, Bornman
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Cybersecurity risk assessment of VDR
Journal of Navigation, 2023AbstractThe voyage data recorder (VDR) is a data recording system that aims to provide all navigational, positional, communicational, sensor, control and command information for data-driven investigation of accidents onboard ships. Due to the increasing dependence on interconnected networks, cybersecurity threats are one of the most severe issues and ...
Ömer Söner +3 more
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Paget’s disease—A VDR coactivator disease?
The Journal of Steroid Biochemistry and Molecular Biology, 2004Paget's disease is the most exaggerated example of bone remodeling with increased osteoclastic bone resorption followed by excessive bone formation. One of the earliest findings in our studies of Paget's disease is that pagetic osteoclast (OCL) precursors are hyper-responsive to 1,25-(OH)(2)D(3) and form OCL at concentrations of 1,25-(OH)(2)D(3) that ...
Kurihara, Noriyoshi +4 more
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SURENKAMOSIOS STATYBOS TIKSLUMO PROBLEMOS VDR
Geodezijos Darbai, 1979РЕЗЮМЕ В статье описываются принятые в ГДР способы геодезических работ и дан анализ их точностей (допусков). при обслуживании строительно—монтажных работ. Приведен анализ допусков выверки строительных конструкций, разбивки и установки стеновых панелей. Установлены такие стандарты: выверка паиелей—Sизм=±0,465пан, разбивка точек монтажных осей Sразб=± 0 ...
Fricas Henekė, Fritz Hennecke
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Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex
Journal of Cellular Biochemistry, 2006AbstractOur previous study demonstrate that vitamin D3 induces the binding of vitamin D3 receptor (VDR) to Sp1 transcription factor and stimulates p27Kip1 expression via the Sp1 consensus sequences in the promoter. Both VDR and Sp1 are transcriptional activators, it is unclear which protein functions as the transcription component of the VDR/Sp1 ...
Hsuen-Tsen, Cheng +4 more
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Clinical calcium, 2005
Typical abnormalities of hereditary rickets type II patients were observed in the mice deficient of VDR with growth retardation, impaired bone formation and alopecia. Except alopecia, all of the abnormalities were rescued by dietary supplement of high minerals.
Shigeaki, Kato, Yamamoto, Yoko
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Typical abnormalities of hereditary rickets type II patients were observed in the mice deficient of VDR with growth retardation, impaired bone formation and alopecia. Except alopecia, all of the abnormalities were rescued by dietary supplement of high minerals.
Shigeaki, Kato, Yamamoto, Yoko
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Mechanistic Analysis of VDR-Mediated Renin Suppression
Nephron Physiology, 2007<i>Background:</i> The vitamin D receptor (VDR) is involved in the regulation of renin expression and vitamin D analogs down-regulated renin mRNA expression in As4.1 cells. <i>Methods:</i> Microarray analysis was used to assess the VDR-mediated gene expression profile in As4.1 cells treated with paricalcitol, followed by real ...
Masaki, Nakane +4 more
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[Cardiovascular effects of VDR and CaSR activation].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2009Cardiovascular complications are the most common cause of death in uremic patients, especially those on chronic dialysis. One of the major findings is massive calcium deposition in the vessel walls. There is general consensus about the correlation between the distribution of vascular calcification and increased risk of death due to cardiovascular ...
D. Brancaccio, M.G. Cozzolino
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