Results 51 to 60 of about 3,198,629 (233)

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Machine learning for predicting severe dengue in Puerto Rico

Infectious Diseases of Poverty
Background Distinguishing between non-severe and severe dengue is crucial for timely intervention and reducing morbidity and mortality. World Health Organization (WHO)-recommended warning signs offer a practical approach for clinicians but have limited ...
Zachary J. Madewell, Dania M. Rodriguez, Maile B. Thayer, Vanessa Rivera-Amill, Gabriela Paz-Bailey, Laura E. Adams, Joshua M. Wong   +6 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure

Scientific Reports
When arthropod-borne viruses (arboviruses) are delivered to vector mosquitoes in infectious bloodmeals, viral components interact with host proteins to hijack cells and initiate replication.
Hunter A. Ogg, Zoey M. Mikol, David C. King, Chad E. Mire, Zeyad Arhouma, Erin Osborne Nishimura, Rebekah C. Kading, Corey L. Campbell   +7 more
doaj   +1 more source

Identification of proteins expressed by Babesia bigemina kinetes

Parasites & Vectors, 2019
Background Babesia bigemina is an apicomplexan parasite transovarially transmitted via Rhipicephalus ticks that infect red blood cells and causes bovine babesiosis, a poorly controlled severe acute disease in cattle.
Gamila A. R. Bohaliga, Wendell C. Johnson, Naomi S. Taus, Hala E. Hussein, Reginaldo G. Bastos, Carlos E. Suarez, Glen A. Scoles, Massaro W. Ueti   +7 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Comparing Different Larval Food Sources and Temperature Regimes for the Rearing of Culicoides obsoletus/scoticus Complex Midges, the Predominant Bluetongue, and Schmallenberg Virus Vectors in Northern Europe

Proceedings, 2020
During the last decade, Europe was confronted with the emergence of two Culicoides-borne viruses, bluetongue virus and Schmallenberg virus. Both diseases caused economic losses in cattle, sheep, and goats. Despite their importance, only limited knowledge
Charlotte Sohier, Severine Matthijs, Nick De Regge   +2 more
doaj   +1 more source

Strategy of Triple‐Gradient in Binary Pixels for Flexible Pressure Sensing with High Sensitivity and Wide‐Range Linearity

Advanced Science, EarlyView.
A flexible pressure sensor with triple‐gradient design of conductivity, modulus, and dimension in binary micro‐dome pixels is proposed. Based on precisely‐designed CNT/PDMS matrix, the device exhibits a linear sensitivity of 974.1 kPa−1 across range up to 1.8 MPa (R2 > 0.99), offering an effective strategy for potential applications in healthcare ...
Yifan Liu, Xiao Xu, Fengming Hu, Yuanzhe Liang, Zidong Yin, Biao Qi, Ruolin Liu, Ziyi Dai, Jianyi Luo, Bingpu Zhou   +9 more
wiley   +1 more source

Identification of a putative methyltransferase gene of Babesia bigemina as a novel molecular biomarker uniquely expressed in parasite tick stages

Parasites & Vectors, 2018
Background Bovine babesiosis is caused by apicomplexan pathogens of the genus Babesia such as B. bigemina and B. bovis. These tick-borne pathogens have a complex life-cycle involving asexual multiplication in vertebrate hosts and sexual reproduction in ...
Gamila A. R. Bohaliga, Wendell C. Johnson, Naomi S. Taus, Hala E. Hussein, Reginaldo G. Bastos, Carlos E. Suarez, Roberta O’Connor, Massaro W. Ueti   +7 more
doaj   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source