Results 61 to 70 of about 3,198,629 (233)

Prion replication in organotypic brain slice cultures is distinct from in vivo inoculation and is species dependent

Acta Neuropathologica Communications
Cultured brain slices rapidly replicate murine prions, exhibit prion pathology, and are amenable towards drug discovery, but have not been infected with human prions.
Jessy A. Slota, Lise Lamoureux, Jennifer Myskiw, Kathy L. Frost, Sarah J. Medina, Dominic M. S. Kielich, Melanie Leonhardt, Gunjan Thapar, Ben A. Bailey-Elkin, Stephanie A. Booth   +9 more
doaj   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Insecticidal efficacy of residual spraying with deltamethrin–clothianidin (Fludora® Fusion) in Papua New Guinea

Parasites & Vectors
Background In Papua New Guinea (PNG), insecticide-treated nets leave considerable gaps in protection from Anopheles mosquito bites and, as a result, malaria cases are increasing.
Evodia Anetul, Petrina Johnson, Rebecca Vinit, Nakei Bubun, Kiari Kiari, Rowena Absalom, Daniel Aulim, Paul Daly, Melanie Koinari, Tiziano Raffaelli, Jason H. Richardson, Michael Macdonald, Jacob Kisomb, Maria Ome-Kaius, Moses Laman, Leanne J. Robinson, Stephan Karl   +16 more
doaj   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

An update of the tsetse fly (Diptera: Glossinidae) distribution and African animal trypanosomosis prevalence in north-eastern KwaZulu-Natal, South Africa

Onderstepoort Journal of Veterinary Research, 2016
An unpredicted outbreak of African animal trypanosomosis or nagana in 1990 in north-eastern KwaZulu-Natal necessitated an emergency control programme, utilising the extensive cattledipping system in the area, as well as a reassessment of the tsetse and ...
Chantel J. de Beer, Gert J. Venter, Karin Kappmeier Green, Johan Esterhuizen, Daniel G. de Klerk, Jerome Ntshangase, Marc J.B. Vreysen, Ronel Pienaar, Makhosazana Motloang, Lundi Ntantiso, Abdalla A. Latif   +10 more
doaj   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Economic burden of dengue in Puerto Rico, 2010–2023

Infectious Diseases of Poverty
Background Dengue remains a major public health challenge, particularly in endemic areas like Puerto Rico, where its economic burden is substantial. This study aimed to update the economic burden of dengue in Puerto Rico using recent data from patients ...
Daniel Camprubí-Ferrer, Maile B. Thayer, Zachary J. Madewell, J. Mac McCullough, Liliana Sánchez-González, Aidsa Rivera, Janice Perez-Padilla, Dania M. Rodriguez, Jomil Torres Aponte, Michael A. Johansson, Gabriela Paz-Bailey, Vanessa Rivera-Amill, Melissa Marzan-Rodriguez, Laura E. Adams   +13 more
doaj   +1 more source

The dynamics of questing ticks collected for 164 consecutive months off the vegetation of two landscape zones in the Kruger National Park (1988–2002). Part III. The less commonly collected species

Onderstepoort Journal of Veterinary Research, 2011
Despite many studies regarding tick ecology, limited information on long-term changes in tick populations exist. This study assessed the long-term population dynamics of the less frequently collected questing ixodid ticks in the Kruger National Park ...
Gordon J. Gallivan, Andrea Spickett, Heloise Heyne, Arthur M. Spickett, Ivan G. Horak   +4 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Current Knowledge on Tick-Borne Encephalitis Virus Interaction with Ticks: Acquisition, Dissemination, and Persistence

Pathogens
Tick-borne encephalitis virus (TBEV) is a major arthropod-borne flavivirus responsible for severe neurological disease in humans across Europe and Asia.
Gabrielle Trozzi, Charlotte Sohier, Nick De Regge   +2 more
doaj   +1 more source