Results 101 to 110 of about 1,466,396 (268)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

First record of Ixodes (Scaphixodes) caledonicus in the Carpathian Basin and first time molecular-phylogenetic analysis of this tick species with updated host records and geographical range

Ticks and Tick-Borne Diseases
Four Ixodes species represent the subgenus Scaphixodes Schulze, 1941 in Europe, but none of them were reported to be compared in a molecular-phylogenetic context. This study compensates for this lack of data.
Sándor Hornok, Jenő Kontschán, Nóra Takács, Péter L. Pap, Attila D. Sándor   +4 more
doaj   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Molecular Diagnosis, Prevalence and Importance of Zoonotic Vector-Borne Pathogens in Cuban Shelter Dogs : A Preliminary Study

, 2020
The present study aimed to determine the prevalence of zoonotic vector-borne pathogens, including Anaplasma platys, Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Ehrlichia canis and Rickettsia spp. in shelter dogs from Cuba.
Roblejo-Arias, Lisset, Lobo Rivero, Evelyn, Osvaldo Fonseca-Rodríguez, Díaz-Sánchez, Adrian Alberto,, Pérez Castillo, Anisleidy, Anisleidy Pérez Castillo, Fonseca Rodriguez, Osvaldo,, Corona-González, Belkis,, Vega Cañizares, Ernesto,, Marina L. Meli, Corona-González, Belkis, Fonseca Rodriguez, Osvaldo, Roblejo-Arias, Lisset,, Lobo Rivero, Evelyn,, Ernesto Vega Cañizares, Pérez Castillo, Anisleidy,, Meli, Marina L,, Adrian Alberto Díaz-Sánchez, Lisset Roblejo-Arias, Díaz-Sánchez, Adrian Alberto, Regina Hofmann-Lehmann, Vega Cañizares, Ernesto, Belkis Corona-González, Hofmann-Lehmann, Regina, Hofmann-Lehmann, Regina,, Evelyn Lobo Rivero, Meli, Marina L   +26 more
core   +1 more source

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, EarlyView.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

Climate Change and Autochthonous Vector-Borne Disease Transmission in Europe: Dengue as a Sentinel Signal for Surveillance and Preparedness

Climate change is reshaping the epidemiology of vector-borne diseases in Europe by altering the ecological conditions that determine vector survival, seasonal activity and pathogen transmission. Rising temperatures, milder winters, prolonged warm seasons
Anna Bogacka, Maciej Grzybek
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

No Bite Zone! A Brief Guide to Insect Repellents [PDF]

Insect repellents are substances that, when used as directed, can reduce tick, mosquito, and other insect bites. Preventing bites will help you avoid disease-causing pathogens carried by these animals.
Northeast Regional Center for Excellence in Vector-Borne Diseases
core   +4 more sources

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

A bite so sweet: the glycobiology interface of tick-host-pathogen interactions

Parasites & Vectors, 2018
Vector-borne diseases constitute 17% of all infectious diseases in the world; among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens
Pavlina Vechtova, Jarmila Sterbova, Jan Sterba, Marie Vancova, Ryan O. M. Rego, Martin Selinger, Martin Strnad, Maryna Golovchenko, Nataliia Rudenko, Libor Grubhoffer   +9 more
doaj   +1 more source