Results 81 to 90 of about 1,466,396 (268)

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Evaluation of blood and bone marrow in selected canine vector-borne diseases

Parasites & Vectors, 2014
Background Bone marrow (BM) is a major hematopoietic organ that can harbour a variety of vector-borne pathogens; however, knowledge of BM pathological changes in dogs infected with vector-borne pathogens is limited. Thus, the aim of the present study was
Anna S De Tommasi, Domenico Otranto, Tommaso Furlanello, Silvia Tasca, Cinzia Cantacessi, Edward B Breitschwerdt, Dorothee Stanneck, Filipe Dantas-Torres, Gad Baneth, Gioia Capelli, Donato de Caprariis   +10 more
doaj   +1 more source

Pathogens spread by high-flying wind-borne mosquitoes [PDF]

Mosquito-borne diseases such as malaria and dengue threaten billions of people and cause the death of hundreds of thousands annually. Recent studies have revealed that many mosquito species regularly engage in high-altitude wind-borne migration, but its ...
Linton, Yvonne-Marie, Lehmann, Tovi, Djibril, S., Akosah-Brempong, Gabriel, Mohammed, A. R., Afrane, Y. A., Krajacich, Benjamin J., Bamou, R., Diallo, M., Sanogo, Z. L., Ergunay, Koray, Escalante, A. A., Kouam, Cedric, Linton, Y., Pacheco, M. Andreina, Bourke, Brian P., Krajacich, B. J., Bamou, Roland, Escalante, Ananias A., Kouam, C., Reynolds, D. R., Djibril, Samake, Mohammed, Abdul Rahim, Afrane, Yaw A., Bourke, B. P., Owusu-Asenso, Christopher M., Faiman, Roy, Nartey, Rita, Nartey, R., Weaver, Scott C., Pambit-Zong, C. M., Sanogo, Zana L., Dao, A., Dao, Adama, Reynolds, Don R., Lehmann, T., Owusu-Asenso, C. M., Faiman, R., Yaro, Alpha S., Pambit-Zong, Cosmos M., Weaver, S. C., Chapman, J. W., Diallo, Moussa, Ergunay, K., Chapman, Jason W., Yaro, A. S., Akosah-Brempong, G., Pacheco, M. A.   +47 more
core   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Applying MALDI-TOF MS to resolve morphologic and genetic similarities between two Dermacentor tick species of public health importance

Scientific Reports
Hard ticks (Acari: Ixodidae) have been historically identified by morphological methods which require highly specialized expertise and more recently by DNA-based molecular assays that involve high costs.
Maria F. B. M. Galletti, Joy A. Hecht, John R. McQuiston, Jarrett Gartin, Jake Cochran, Bessie H. Blocher, Bryan N. Ayres, Michelle E. J. Allerdice, Lorenza Beati, William L. Nicholson, Alyssa N. Snellgrove, Christopher D. Paddock, US Tick MALDI-TOF consortium   +12 more
doaj   +1 more source

Ixodid ticks of Western Palearctic bats: ecology, host-parasite relationships, geographic distribution and zoonotic importance

Frontiers in Veterinary Science
Bats in the Western Palearctic are host for diverse array of ectoparasites, including three ixodid ticks (Ixodes ariadnae, I. simplex, and I. vespertilionis), which are highly specialized to parasitize these mammals.
Attila D. Sándor, Attila D. Sándor, Attila D. Sándor, Cristian Domșa, Áron Péter, Sándor Hornok, Sándor Hornok   +6 more
doaj   +1 more source

Parasites and wildlife in a changing world: The vector-host- pathogen interaction as a learning case

International Journal for Parasitology: Parasites and Wildlife, 2019
In the Anthropocene context, changes in climate, land use and biodiversity are considered among the most important anthropogenic factors affecting parasites-host interaction and wildlife zoonotic diseases emergence. Transmission of vector borne pathogens
Annapaola Rizzoli, Valentina Tagliapietra, Francesca Cagnacci, Giovanni Marini, Daniele Arnoldi, Fausta Rosso, Roberto Rosà   +6 more
doaj   +1 more source

Tick-Borne Diseases and Pregnancy: A Narrative Review Evaluating Pregnancy Complications Caused by Tick-Borne Diseases [PDF]

Ticks are vectors of public health concern because the pathogens they transmit can cause detrimental diseases in humans. Lyme disease, tick-borne relapsing fever, human granulocytic anaplasmosis, Rocky Mountain spotted fever, tick-borne encephalitis ...
Michael W. Curtis, Job E. Lopez, Lopez, Job E, Curtis, Michael W   +3 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source