Results 221 to 230 of about 1,466,396 (268)

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Molecular and Serological Detection of Vector-Borne Pathogens Responsible for Equine Piroplasmosis in Europe between 2008 and 2021. [PDF]

Microorganisms
Axt CW, Springer A, Strube C, Jung C, Naucke TJ, Müller E, Schäfer I.   +6 more
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Metabarcoding using nanopore sequencing enables identification of diverse and zoonotic vector-borne pathogens from neglected regions: A case study investigating dogs from Bhutan. [PDF]

One Health
Huggins LG, Namgyel U, Wangchuk P, Atapattu U, Traub R, Colella V.   +5 more
europepmc   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Nonstationarity in wildlife disease dynamics: insights from the prairie dog–plague system

Oikos, EarlyView.
Ecological relationships often vary in strength and direction across ecosystems, a pattern that has become increasingly evident as ecology expands to broader spatial and temporal scales. Although such nonstationarity – the changing effect of predictor variables across spatiotemporal contexts – is widely acknowledged in ecological research, it has ...
Gabriel M. Barrile, Joshua F. Layfield, David J. Augustine, Lauren M. Porensky, Courtney J. Duchardt, Imtiaz Rangwala, Ana D. Davidson   +6 more
wiley   +1 more source

Capsicum chinense as an African traditional vegetable: Culture, resilience, and opportunity

PLANTS, PEOPLE, PLANET, EarlyView.
Capsicum chinense is central to everyday diets, cultural identity, and smallholder livelihoods across Sub‐Saharan Africa, yet remains overlooked in agricultural research and policy. This paper reframes C. chinense as a traditional, climate‐resilient vegetable shaped by centuries of farmer stewardship and cultural selection.
Derek W. Barchenger, Herbaud P. F. Zohoungbogobo   +1 more
wiley   +1 more source

Disease control in oilseed rape: Current insights and perspectives for next‐generation integrated pest management

Pest Management Science, EarlyView.
Winter oilseed rape in Europe suffers frequent pathogen losses. This review outlines key integrated pest management (IPM) strategies, rotation, residue and tillage management, optimized sowing, resistance, and targeted fungicides supported by forecasting.
Jon S West, Małgorzata Jędryczka, Nazanin Zamani‐Noor   +2 more
wiley   +1 more source

Development and deployment of a risk assessment index as a decision‐support tool for managing whitefly‐transmitted viruses affecting squash

Pest Management Science, EarlyView.
A data‐driven framework identified planting date and row cover as dominant drivers of whitefly‐transmitted virus complex (WTVC) risk in squash. Integration into the SquashRx mobile application enables real‐time risk assessment and supports improved decision‐making for integrated pest management.
Clarence B Codod, Anoop A Malik, Alton N Sparks Jr., Andre Luiz Biscaia Ribeiro da Silva, Paul M Severns, Joara Candian, Rajagopalbabu Srinivasan, Ty Torrance, Robert C Kemerait Jr., Bhabesh Dutta   +9 more
wiley   +1 more source