Results 51 to 60 of about 1,466,396 (268)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Rickettsia conorii Subspecies israelensis in Captive Baboons

Emerging Infectious Diseases, 2023
Hamadryas baboons (Papio hamadryas) may transmit zoonotic vector-borne pathogens to visitors and workers frequenting zoological parks. We molecularly screened 33 baboons for vector-borne pathogens.
Giovanni Sgroi, Roberta Iatta, Grazia Carelli, Annamaria Uva, Maria Alfonsa Cavalera, Piero Laricchiuta, Domenico Otranto   +6 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

A review on the role of birds as disseminators of ticks, with special emphasis on Hyalomma species and Crimean-Congo haemorrhagic fever virus

Ticks and Tick-Borne Diseases
Hyalomma marginatum and Hyalomma rufipes are tick species of high medical importance, primarily due to their ability to transmit the Crimean-Congo haemorrhagic fever virus. While H. marginatum is endemic in Southern Europe, H.
Gergő Keve, Attila D. Sándor, Sándor Hornok   +2 more
doaj   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Detection of vector-borne pathogens in cats and their ectoparasites in southern Italy [PDF]

Parasites & Vectors, 2016
Vector-borne pathogens are the subject of several investigations due to the zoonotic concern of some of them. However, limited data are available about the simultaneous presence of these pathogens in cats and their ectoparasites. The aim of the present study was to define the species of ectoparasites found on cats as well as to investigate vector-borne
Persichetti, Maria Flaminia, Solano Gallego, Laia, Serrano, Lorena, Altet, Laura, Reale, Stefano, MASUCCI, Marisa, PENNISI, Maria Grazia   +6 more
openaire   +4 more sources

High-throughput detection of eukaryotic parasites and arboviruses in mosquitoes

Biology Open, 2021
Vector-borne pathogens cause many human infectious diseases and are responsible for high mortality and morbidity throughout the world. They can also cause livestock epidemics with dramatic social and economic consequences.
Matthew V. Cannon, Haikel N. Bogale, Devika Bhalerao, Kalil Keita, Denka Camara, Yaya Barry, Moussa Keita, Drissa Coulibaly, Abdoulaye K. Kone, Ogobara K. Doumbo, Mahamadou A. Thera, Christopher V. Plowe, Mark A. Travassos, Seth R. Irish, Joshua Yeroshefsky, Jeannine Dorothy, Brian Prendergast, Brandyce St. Laurent, Megan L. Fritz, David Serre   +19 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Season and host-community composition inside roosts may affect host-specificity of bat flies

Scientific Reports
Bat flies are one of the most abundant ectoparasites of bats, showing remarkable morphological adaptations to the parasitic habit, while the relationship with their hosts is characterized by a high level of specificity.
Attila D. Sándor, Alexandra Corduneanu, Sándor Hornok, Andrei D. Mihalca, Áron Péter   +4 more
doaj   +1 more source

Information Transmission Strategies for Self‐Organized Robotic Aggregation

Advanced Robotics Research, EarlyView.
In this review, we discuss how information transmission influences the neighbor‐based self‐organized aggregation of swarm robots. We focus specifically on local interactions regarding information transfer and categorize previous studies based on the functions of the information exchanged.
Shu Leng, Zihan Li, Yifeng Shao, Jinhao Liu, Li Yu, Shuguang Li   +5 more
wiley   +1 more source