Results 41 to 50 of about 1,674,962 (266)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

Molecular Therapy: Methods & Clinical Development, 2017
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman   +17 more
doaj   +1 more source

Diversity and potential distribution of culicids of medical importance of the Yucatan Peninsula, Mexico

Salud Pública de México, 2020
Objective. To determine the species distribution, abun­dance, and diversity of culicids in the Yucatan Peninsula (YP); their potential distribution, using ecological niche modeling (ENM), and the risk of contact with urban and rural popula­tions ...
J Guillermo Bond, David A Moo-Llanes, Aldo I Ortega-Morales, Carlos F Marina, Mauricio Casas-Martínez, Rogelio Danis-Lozano   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A viral movement protein mediates host volatile biosynthesis to co-attract vectors and non-vectors and enhances viral infection

Frontiers in Plant Science
The literature shows that vector-transmitted plant viruses mediate host volatile biosynthesis to attract vectors and repel non-vectors, benefiting plant-infecting viruses and enhancing their spread.
Shijun Li, Xiangwen Luo, Xiangwen Luo, Xiangwen Luo, Yu Zhang, Yu Zhang, Zhanhong Zhang, Zhanhong Zhang, Zhanhong Zhang, Xiao Yang, Xiao Yang, Xuguo Zhou, Xin Wang, Xian OuYang, Xian OuYang, Xiaoxin Qu, Deyong Zhang, Deyong Zhang, Deyong Zhang, Deyong Zhang, Songbai Zhang, Songbai Zhang, Songbai Zhang, Songbai Zhang, Yong Liu, Yong Liu, Yong Liu, Yong Liu   +27 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Identification of Novel Zoonotic Activity of Bartonella spp., France

Emerging Infectious Diseases, 2016
Certain Bartonella species are known to cause afebrile bacteremia in humans and other mammals, including B. quintana, the agent of trench fever, and B. henselae, the agent of cat scratch disease.
Muriel Vayssier-Taussat, Sara Moutailler, Françoise Féménia, Philippe Raymond, Olivier Croce, Bernard La Scola, Pierre-Edouard Fournier, Didier Raoult   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evaluation of seed dressing insecticides for the control of maize lethal necrosis vectors

Cogent Food & Agriculture
Most of the overwhelming plant diseases caused by viruses including maize lethal necrosis (MLN) are attributed to viruses transmitted by vectors. The transmission of MLN from plant to plant by vectors provides the main means of spread in the field and ...
Bayissa Regassa, Adane Abraham, Chemeda Fininsa, Yitbarek Wolde-Hawariat, Dagne Wegary   +4 more
doaj   +1 more source