Results 81 to 90 of about 3,417,786 (378)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Spatial Studies on Vector-Transmitted Diseases and Vectors [PDF]

Journal of Tropical Medicine, 2012
1 Laboratorio de Transmissores de Hematozoarios, Fundacao Oswaldo Cruz, Avenida Brasil 4365 Manguinhos, 21045-900 Rio de Janeiro, RJ, Brazil 2 Programa de Computacao Cientifica, Fundacao Oswaldo Cruz, 21045-900 Rio de Janeiro, RJ, Brazil 3 Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, 20550-900 Rio de Janeiro, RJ, Brazil 4 IRD
Rosa-Freitas, Maria Goreti, Honório, Nildimar Alves, Torres Codeço, Cláudia, Loureiro Werneck, Guilherme, Dégallier, Nicolas   +4 more
openaire   +8 more sources

West Nile Virus Outbreak in Houston and Harris County, Texas, USA, 2014

Emerging Infectious Diseases, 2017
Since 2002, West Nile virus (WNV) has been detected every year in Houston and the surrounding Harris County, Texas. In 2014, the largest WNV outbreak to date occurred, comprising 139 cases and causing 2 deaths.
Diana Martinez, Kristy O. Murray, Martin Reyna, Raouf R. Arafat, Roberto Gorena, Umair A. Shah, Mustapha Debboun   +6 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Stability properties of divergence-free vector fields [PDF]

arXiv, 2010
A divergence-free vector field satisfies the star property if any divergence-free vector field in some C1-neighborhood has all singularities and all periodic orbits hyperbolic. In this paper we prove that any divergence-free vector field defined on a Riemannian manifold and satisfying the star property is Anosov. It is also shown that a C1-structurally
arxiv  

Permanental vectors

Stochastic Processes and their Applications, 2012
A permanental vector is a generalization of a vector with components that are squares of the components of a Gaussian vector, in the sense that the matrix that appears in the Laplace transform of the vector of Gaussian squares is not required to be either symmetric or positive definite.
Kogan, Hana, Marcus, Michael B.
openaire   +2 more sources

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

Molecular Therapy: Methods & Clinical Development, 2017
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman   +17 more
doaj   +1 more source

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Several polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--i.e., without the addition of cell targeting or membrane-disruption agents.
O. Boussif, F. Lezoualc’h, M. Zanta, M. Mergny, D. Scherman, B. Demeneix, J. Behr   +6 more
semanticscholar   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source