Results 91 to 100 of about 332,430 (353)
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti+3 more
wiley +1 more source
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale+9 more
wiley +1 more source
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran+16 more
wiley +1 more source
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti+8 more
wiley +1 more source
Polystable bundles and representations of their automorphisms
Using a quasi-linear version of Hodge theory, holomorphic vector bundles in a neighbourhood of a given polystable bundle on a compact Kähler manifold are shown to be (poly)stable if and only if their corresponding classes are (poly)stable in the sense of
Buchdahl Nicholas, Schumacher Georg
doaj +1 more source
Canonical Involution on Double Jet Bundles [PDF]
In this study, we generalize double tangent bundles to double jet bundles. We present a secondary vector bundle structure on a 1-jet of a vector bundle. We show that 1-jet of a vector bundle carries two vector bundle structures, namely primary and secondary structures.
arxiv
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Splitting 3-plane sub-bundles over the product of two real projective spaces
Let α be a real vector bundle of fiber dimension three over the product RP(m)×RP(n) which splits as a Whitney sum of line bundles. We show that the necessary and sufficient conditions for α to embed as a sub-bundle of a certain family of vector bundles β of
Maria Hermínia de Paula Leite Mello+1 more
doaj
Monads and vector bundles on quadrics [PDF]
Abstract We improve Ottaviani's splitting criterion for vector bundles on a quadric hypersurface and obtain the equivalent of the result by Rao, Mohan Kumar and Peterson. Then we give the classification of rank 2 bundles without “inner” cohomology on 𝒬 n (n > 3).
openaire +4 more sources
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin+14 more
wiley +1 more source