Results 81 to 90 of about 43,628 (311)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Atiyah Class of a dg-Vector Bundle
, 2015 We introduce the notions of Atiyah class and Todd class of a differential graded vector bundle with respect to a differential graded Lie algebroid. We prove that the space of vector fields X(M) on a dg-manifold M with homological vector field Q admits a ...
Ping Xu +5 more
core +1 more source
A Geometric characterization of Finsler manifolds of constant curvature K=1
International Journal of Mathematics and Mathematical Sciences, 2000 We prove that a Finsler manifold 𝔽m is of constant curvature K=1 if and only if the unit horizontal Liouville vector field is a Killing vector field on the indicatrix bundle IM of 𝔽m.
A. Bejancu, H. R. Farran
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Positivity of Schur forms for strongly decomposably positive vector bundles
Forum of Mathematics, SigmaIn this paper, we define two types of strongly decomposable positivity, which serve as generalizations of (dual) Nakano positivity and are stronger than the decomposable positivity introduced by S. Finski.
Xueyuan Wan
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
On a Lie Algebraic Characterization of Vector Bundles
Symmetry, Integrability and Geometry: Methods and Applications, 2012 We prove that a vector bundle π: E→M is characterized by the Lie algebra generated by all differential operators on E which are eigenvectors of the Lie derivative in the direction of the Euler vector field.
Pierre B.A. Lecomte +2 more
doaj +1 more source
Elliptic operators on refined Sobolev scales on vector bundles
Open Mathematics, 2017 We introduce a refined Sobolev scale on a vector bundle over a closed infinitely smooth manifold. This scale consists of inner product Hörmander spaces parametrized with a real number and a function varying slowly at infinity in the sense of Karamata. We
Zinchenko Tetiana
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source