Results 61 to 70 of about 280,723 (307)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Chern classes of tropical vector bundles [PDF]
arXiv, 2009 We introduce tropical vector bundles, morphisms and rational sections of these bundles and define the pull-back of a tropical vector bundle and of a rational section along a morphism. Afterwards we use the bounded rational sections of a tropical vector bundle to define the Chern classes of this bundle and prove some basic properties of Chern classes ...
arxiv
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Canonical Involution on Double Jet Bundles [PDF]
arXiv, 2016 In this study, we generalize double tangent bundles to double jet bundles. We present a secondary vector bundle structure on a 1-jet of a vector bundle. We show that 1-jet of a vector bundle carries two vector bundle structures, namely primary and secondary structures.
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Flat Vector Bundles over Parallelizable Manifolds [PDF]
arXiv, 1997 We study flat vector bundles over complex parallelizable manifolds.
arxiv
Sobre la convergencia en el Grassmaniano
Selecciones Matemáticas, 2020 In this paper, we present a characterization of the convergence on the n-th order Grassmannian that permits us to show in a direct way that this set is compact and every vector bundle is measurable.
Helmuth Villavicencio
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Lifting vector bundles to Witt vector bundles
, 2018 Let $p$ be a prime, and let $S$ be a scheme of characteristic $p$. Let $n \geq 2$ be an integer. Denote by $\mathbf{W}_n(S)$ the scheme of Witt vectors of length $n$, built out of $S$. The main objective of this paper concerns the question of extending (=
Arteche, Giancarlo Lucchini +2 more
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