Results 81 to 90 of about 280,723 (307)
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Parabolic k-ample bundles [PDF]
arXiv, 2011 We construct projectivization of a parabolic vector bundle and a tautological line bundle over it. It is shown that a parabolic vector bundle is ample if and only if the tautological line bundle is ample. This allows us to generalize the notion of a k-ample bundle, introduced by Sommese, to the context of parabolic bundles.
arxiv
Vector bundles and differential bundles in the category of smooth manifolds [PDF]
arXiv, 2020 A tangent category is a category equipped with an endofunctor that satisfies certain axioms which capture the abstract properties of the tangent bundle functor from classical differential geometry. Cockett and Cruttwell introduced differential bundles in 2017 as an algebraic alternative to vector bundles in an arbitrary tangent category. In this paper,
arxiv
Vector bundles on rational homogeneous spaces. [PDF]
Ann Mat Pura Appl, 2021 Du R, Fang X, Gao Y.
europepmc +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Complex Finsler structures on CR-holomorphic vector bundles [PDF]
Rendiconti di Matematica e delle Sue Applicazioni, 1999 For any CR-holomorphic vector bundle (in the sense of N. Tanaka, [16]) E, over a strictly pseudoconvex CR manifold M, equipped with a convex complex Finsler structure F, we build a connection D in the pullback bundle π∗E of E by π : E \ {0} −→M, similar ...
Sorin Dragomir, Peter Nagy
doaj
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Multiple vector bundles: cores, splittings and decompositions [PDF]
arXiv, 2018 This paper introduces $\infty$- and $n$-fold vector bundles as special functors from the $\infty$- and $n$-cube categories to the category of smooth manifolds. We study the cores and "n-pullbacks" of $n$-fold vector bundles and we prove that any $n$-fold vector bundle admits a non-canonical isomorphism to a decomposed $n$-fold vector bundle.
arxiv
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source