Results 131 to 140 of about 2,190,858 (340)

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Vector Competence of Italian Populations of Culicoides for Some Bluetongue Virus Strains Responsible for Recent Northern African and European Outbreaks

Viruses, 2019
The distribution of Bluetongue virus (BTV) in Europe can be represented by two distinct and interconnected epidemiological systems (episystems), each characterized by different ecological characteristics and vector species.
Valentina Federici, Maria Goffredo, Giuseppe Mancini, Michela Quaglia, Adriana Santilli, Francesca Di Nicola, Matteo De Ascentis, Pierangela Cabras, Carmela Volpicelli, Claudio De Liberato, Giuseppe Satta, Giovanni Federico, Alessandra Leone, Maura Pisciella, Ottavio Portanti, Federica Pizzurro, Liana Teodori, Giovanni Savini   +17 more
doaj   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

Experimental design impacts the vector competence of Ornithodoros ticks for African swine fever virus: a meta-analysis of published evaluations

Peer Community Journal
African Swine Fever (ASF) is a highly economically devastating viral disease for swine. Soft ticks of the genus Ornithodoros are involved in its epidemiology, as vectors and natural reservoirs of African Swine Fever Virus (ASFV). The vector competence of
Bernard, Jennifer, Vial, Laurence, Madeira, Sara, Otte, Joachim, Boinas, Fernando, Le Potier, Marie-Frédérique, Jourdan-Pineau, Hélène   +6 more
doaj   +1 more source

Endogenous non-retroviral elements in genomes of Aedes mosquitoes and vector competence

Emerging Microbes and Infections, 2019
Recent extensive (re)emergences of arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV), zika (ZIKV) and dengue (DENV) viruses highlight the role of the epidemic vectors, Aedes aegypti and Aedes albopictus, in their spreading. Differences of
V. Houé, M. Bonizzoni, A. Failloux
semanticscholar   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes

Insects, 2015
Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of
Joy Kean, Stephanie M. Rainey, Melanie McFarlane, Claire L. Donald, Esther Schnettler, Alain Kohl, Emilie Pondeville   +6 more
doaj   +1 more source

Effect of overwintering on survival and vector competence of the West Nile virus vector Culex pipiens

Parasites & Vectors, 2019
West Nile virus (WNV) is a mosquito-borne virus that is mainly transmitted among birds by Culex pipiens mosquitoes. The species Cx. pipiens consists of two biotypes named pipiens and molestus, which together can form hybrids.
C. Koenraadt, Tim W R Möhlmann, N. Verhulst, J. Spitzen, C. Vogels   +4 more
semanticscholar   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Vector biology prospects in dengue research

Memorias do Instituto Oswaldo Cruz, 2012
We argue that using more natural blood feeding methods to study mosquito vector competence for dengue viruses and exploring the effect of viral infection on other mosquito life-history traits that influence vectorial capacity will significantly advance ...
Louis Lambrechts, Anna-Bella Failloux
doaj   +1 more source