Results 181 to 190 of about 37,265 (258)

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source

Exploring the microbiomes of camel ticks to infer vector competence: insights from tissue-level symbiont-pathogen relationships. [PDF]

Sci Rep
Khogali R, Bastos A, Getange D, Bargul JL, Kalayou S, Ongeso N, Verhoeven JTP, Kabii J, Ngiela J, Masiga D, Villinger J.   +10 more
europepmc   +2 more sources

Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes. [PDF]

Nat Commun
Sun X, Wang Y, Yuan F, Zhang Y, Kang X, Sun J, Wang P, Lu T, Sae Wang F, Gu J, Wang J, Xia Q, Xia Q, Zheng A, Zou Z.   +14 more
europepmc   +1 more source

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Brian Davis, Roger B. Dodd, Christine Surrette, John Nelson   +8 more
wiley   +1 more source

Is vector competence testing of Aedes aegypti a valid tool to determine the transmission potential of yellow fever virus? [PDF]

New Microbes New Infect
Taylor-Robinson AW.
europepmc   +1 more source

Contrasting roles of school and public libraries in lower primary pupils' reading

British Educational Research Journal, EarlyView.
Abstract Libraries represent an important institutional component of children's reading socialisation, yet their role is often treated as uniform despite substantial differences between school and public libraries. This study examines how visits to school and public libraries relate to pupils' reading attitudes, practices and self‐assessed reading ...
Kateřina Balcarová, Jiří Balcar
wiley   +1 more source

Laboratory evidence on the vector competence of European field-captured Culex theileri for circulating West Nile virus lineages 1 and 2. [PDF]

Parasit Vectors
Burgas-Pau A, Gardela J, Aranda C, Verdún M, Rivas R, Pujol N, Figuerola J, Busquets N.   +7 more
europepmc   +1 more source

A Guide to Bayesian Optimization in Bioprocess Engineering

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small data sets, and provide adaptive suggestions for sequential experimentation.
Maximilian Siska, Emma Pajak, Katrin Rosenthal, Antonio del Rio Chanona, Eric von Lieres, Laura M. Helleckes   +5 more
wiley   +1 more source

Vector Competence of Aedes aegypti from São Tomé and Príncipe for West Nile Virus Transmission. [PDF]

Microorganisms
Marmé R, Tomaz F, Sousa CA, Pinto J, Lanzaro GC, Parreira R, Seixas G.   +6 more
europepmc   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source