Results 301 to 310 of about 143,524 (331)

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Detection of Harmonic and Interharmonics Contents in Water Desalination Plants' Distribution System Based on Deep Learning Algorithms

Energy Science &Engineering, EarlyView.
Developed harmonics and interharmonics detection framework. ABSTRACT Water desalination plants are significant consumers of electric power, making them some of the largest energy users in power grids. Their electricity consumption presents an urgent challenge for efficient and sustainable operation, and they are among the most power‐quality‐threatening
Hasnaa M. El‐Arwash, Maytham Alabid, Ragab A. El‐Sehiemy, Lamiaa A. A. Said   +3 more
wiley   +1 more source

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Mosquito Immunobiology: The Intersection of Vector Health and Vector Competence

Annual Review of Entomology, 2018
As holometabolous insects that occupy distinct aquatic and terrestrial environments in larval and adult stages and utilize hematophagy for nutrient acquisition, mosquitoes are subjected to a wide variety of symbiotic interactions. Indeed, mosquitoes play host to endosymbiotic, entomopathogenic, and mosquito-borne organisms, including protozoa, viruses,
Kristin Michel, Lyric C. Bartholomay
openaire   +2 more sources

Vector Competence of Australian Mosquitoes for Chikungunya Virus

Vector-Borne and Zoonotic Diseases, 2010
Chikungunya virus (CHIKV) is a globally emerging arbovirus responsible for unprecedented outbreaks in the western Indian Ocean, the Indian subcontinent and Italy. To assess the receptivity of Australia to CHIKV, we exposed 10 Australian mosquito species to a 2006 strain of CHIKV isolated from a viremic traveler from Mauritius. In susceptibility trials,
Van Den Hurk, AF, Hall-Mendelin, S, Pyke, AT, Smith, GA, Mackenzie, JS   +4 more
openaire   +4 more sources

Replicating-Competent VSV-Vectored Pseudotyped Viruses

2023
Vesicular stomatitis virus (VSV) is prototype virus in the family of Rhabdoviridae. Reverse genetic platform has enabled the genetic manipulation of VSV as a powerful live viral vector. Replicating-competent VSV is constructed by replacing the original VSV glycoprotein gene with heterologous envelope genes. The resulting recombinant viruses are able to
Fei, Yuan, Aihua, Zheng
openaire   +2 more sources

Generation of Replication-Competent and -Defective HSV Vectors

Cold Spring Harbor Protocols, 2011
INTRODUCTIONEngineering effective vectors has been crucial to the efficient delivery and expression of therapeutic gene products in vivo. Among these, HSV-1 represents an excellent candidate vector for delivery to the peripheral and central nervous systems. The natural biology of HSV-1 includes the establishment of a lifelong latent state in neurons in
William F. Goins, Darren Wolfe, James B. Wechuck, David Krisky, Joseph C. Glorioso, Shaohua Huang   +5 more
openaire   +3 more sources

Vector Competence Assays for RVFV in Mosquitoes

Rift Valley fever virus (RVFV) is the causative agent of Rift Valley fever, a mosquito-borne zoonotic febrile illness that primarily affects ruminants, camels, and humans. It is endemic in sub-Saharan Africa and the Arabian Peninsula, albeit with the potential to spread to and establish in non-endemic countries where mosquito vectors are present ...
Lotty, Birnberg, Núria, Busquets
openaire   +2 more sources

Influences of the Mosquito Microbiota on Vector Competence

2016
Abstract Mosquitoes have a diverse intestinal microbiota which plays essential roles in a variety of the insect's physiological functions. This microbiota can also influence vector competence for human pathogens in multiple ways, including immune system activation or suppression, the regulation of other physiological processes, direct inhibition of ...
S. van Tol, George Dimopoulos
openaire   +2 more sources

[14] Replication-competent and -defective retrovirus vectors for oncogenic studies

1995
Publisher Summary This chapter presents the various vectors that are available for oncogenic studies in avian and mammalian species and provides some technical data on their preparation and use. This experimental approach is useful in analyzing the behavior of tumor cells when these cells are replaced in the environment of normal tissues.
Samarut, Jacques, Flamant, Frederic, Heard, J.M.   +2 more
openaire   +3 more sources

Genetics of Insect Vector Competence for Arboviruses

1994
Ever since arthropods were first incriminated as vectors of disease, medical and veterinary entomologists have recognized that identification of the particular arthropod species transmitting a disease agent is critical for understanding disease epidemiology and for effective disease control.
openaire   +2 more sources