Results 91 to 100 of about 8,483,852 (303)

Comparing the Effectiveness of Malaria Vector-Control Interventions Through a Mathematical Model. [PDF]

, 2010
Although some malaria-control programs are beginning to combine insecticide-treated nets (ITNs) and indoor residual spraying (IRS), little is known about the effectiveness of such combinations.
Steketee, Richard, Chitnis, N., Schapira, A., Chitnis, Nakul, Steketee, R., Richard Steketee, Schapira, Allan, Nakul Chitnis, Allan Schapira, Smith, Thomas, Thomas Smith, Smith, T.   +11 more
core   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Impact of Climatic Factors on the Temporal Trend of Malaria in India from 1961 to 2021

Tropical Medicine and Infectious Disease
Malaria remains a significant public health problem in India. Although temperature influences Anopheline mosquito feeding intervals, population density, and longevity, the reproductive potential of the Plasmodium parasite and rainfall influence the ...
Muniaraj Mayilsamy, Rajamannar Veeramanoharan, Kamala Jain, Vijayakumar Balakrishnan, Paramasivan Rajaiah   +4 more
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Hospitalization of Field Museum

, 1918
Memorandum specification completed by the architectural firm Graham, Anderson, Probst and White for the trustees of the Field Museum. The specification was developed to outline the construction and finishing work for converting the existing ...
Graham, Anderson, Probst and White
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

A New Gilliam Genotypic Variant of Orientia tsutsugamushi in Human Scrub Typhus Cases from South India

Microorganisms
Scrub typhus, caused by Orientia tsutsugamushi (Ot), is a re-emerging public health concern across Southeast Asia. Although multiple Ot strains have been identified in endemic regions, their genetic characterization in India remains limited.
Steny Vallomkottu Joseph, Krishnamoorthy Nallan, Gopinathan Rajan, Amudhan Murugesan, Renu Govindarajan, Raju Sivadoss, Ramkumar Ramalingam, Rajarathinam Kannan Madhumitha, Sucila Thangam Ganesan, Suria Kumar Jayakumar, Manju Rahi, Paramasivan Rajaiah   +11 more
doaj   +1 more source

Pascal's Formulas and Vector Fields

The Electronic Journal of Combinatorics
We consider four examples $T=(T(n,k))_{0\le k\le n}$ of combinatorial triangles (Pascal, Stirling of both types, Euler) : through saddle-point asymptotics, their Pascal's formulas define four vector fields, together with their field lines that turn out to be the conjectured limit of sample paths of four well known Markov chains.
Philippe Chassaing, Jules Flin, Alexis Zevio   +2 more
openaire   +2 more sources

Vector Fall 2015

, 2015
Vector is the student engineering magazine on campus. Published by the Student Engineering Council, Vector is completely written, managed, and designed by students for students.
University of Texas at Austin
core   +1 more source