Results 11 to 20 of about 1,099,631 (289)
Autoregressive fragment-based diffusion for pocket-aware ligand design [PDF]
arXiv, 2023 In this work, we introduce AutoFragDiff, a fragment-based autoregressive diffusion model for generating 3D molecular structures conditioned on target protein structures. We employ geometric vector perceptrons to predict atom types and spatial coordinates of new molecular fragments conditioned on molecular scaffolds and protein pockets.
Beroza, Paul +3 more
arxiv +2 more sources
A topological approach for protein classification [PDF]
arXiv, 2015 Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology. Protein classification, which is typically done through measuring the similarity be- tween proteins based on protein sequence or ...
Cang, Zixuan +5 more
arxiv +3 more sources
[Molecular biology of adenoviral vectors].
Cirugia y cirujanos, 2007 Gene therapy is based on the use of DNA as a therapeutic material as an alternative therapeutic tool for treatment of human diseases. All proteins are codified into the DNA and several diseases result from the absence or aberrant expression of one or related genes, absence of expression of functional proteins, and alterations for regulation process in ...
Francisco Martínez-Flores +2 more
openalex +2 more sources
Current Communications in Molecular Biology: Viral Vectors. Edited by Yakov Gluzman and Stephen H. Hughes. New York: Cold Spring Harbor Laboratory. 1988. 180 pages. Paper $20.00. [PDF]
Genetical Research, 1989 Julian F. Burke
openalex +3 more sources
Vector Control: Insights Arising from the Post-Genomics Findings on Insects’ Reproductive Biology [PDF]
, 2022 The high prevalence of neglected vector-borne diseases, such as Chagas disease and dengue fever, imposes enormous health and financial burdens in developing countries.
Gomes, Fabio, Ramos, Isabela
core +2 more sources
Bridging the gaps in vector biology [PDF]
EMBO reports, 2006 ![][1] This EMBO Workshop on the Molecular and Population Biology of Mosquitoes and other Disease Vectors took place between 22 and 30 July 2005 in Kolymbari, Crete, Greece. The workshop was organized by C. Louis (Chair), B. Beaty, N. Besansky, P. Brey, M. Coetzee, F. Collins, D. Fontenille, J. Hemingway, J. Hoffmann, A.A. James, F.C. Kafatos, J. Law,
Anthony A. James, David Schneider
openaire +3 more sources
CRISPR/Cas9 and genetic screens in malaria parasites : small genomes, big impact [PDF]
, 2022 The ∼30 Mb genomes of the Plasmodium parasites that cause malaria each encode ∼5000 genes, but the functions of the majority remain unknown. This is due to a paucity of functional annotation from sequence homology, which is compounded by low genetic ...
Bushell, Ellen S. C. +4 more
core +1 more source
Gametocytes: insights gained during a decade of molecular monitoring [PDF]
, 2008 In vertebrate hosts, malaria parasites produce specialized male and female sexual stages (gametocytes). Soon after being taken up by a mosquito, gametocytes rapidly produce gametes and, once mated, they infect their vector and can be transmitted to new ...
Abdel-Wahab +81 more
core +2 more sources