Results 41 to 50 of about 223,895 (260)

Stability kernel of vector optimization problems under perturbations of criterion functions

Доповiдi Нацiональної академiї наук України, 2021
The article is devoted to the study of the influence of uncertainty in initial data on the solutions of optimization multicriterial problems. In the optimization problems, including problems with vector criterion, small perturbations in initial data can
Т.Т. Lebedeva, N.V. Semenova, T.I. Sergienko   +2 more
doaj   +1 more source

Bifurcations of Optimal Vector Fields [PDF]

Mathematics of Operations Research, 2015
We study the structure of the solution set of a class of infinite-horizon dynamic programming problems with one-dimensional state spaces, as well as their bifurcations, as problem parameters are varied. The solutions are represented as the integral curves of a multivalued optimal vector field on state space.
Kiseleva, T., Wagener, F.
openaire   +6 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Vector-Valued Optimal Mass Transport [PDF]

SIAM Journal on Applied Mathematics, 2018
16 pages, 8 ...
Yongxin Chen, Tryphon T. Georgiou, Allen Tannenbaum   +2 more
openaire   +5 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

About one discrete analog of Hausdorff semi-continuity of suitable mapping in a vector combinatorial problem with a parametric principle of optimality ("from Slater to lexicographic")

Journal of Numerical Analysis and Approximation Theory, 2006
multicriteria linear combinatorial problem is considered, principle of optimality of which is defined by a partitioning of partial criteria onto groups with Slater preference relation within each group and the lexicographic preference relation ...
Vladimir A. Emelichev, Andrey A. Platonov   +1 more
doaj   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

GENERALIZATION ALGORITHM OF PROBLEM SOLUTION FOR VECTOR OPTIMIZATION THROUGH TWO INDEXES AND CHOOSE FLEXIBLE TECHNOLOGY FOR CARS REPAIR

Nauka ta progres transportu, 2010
The mathematical formulation of solution algorithm for a vector optimization problem on two indices with regard to scientific substantiation of a flexible line of car repair is presented in the ...
V. V. Myamlin, A. A. Bosov, S. V. Myamlin   +2 more
doaj  

Connectedness and Path Connectedness of Weak Efficient Solution Sets of Vector Optimization Problems via Nonlinear Scalarization Methods

Mathematics, 2019
The connectedness and path connectedness of the solution sets to vector optimization problems is an important and interesting study in optimization theories and applications.
Xin Xu, Yang Dong Xu
doaj   +1 more source