Results 91 to 100 of about 49,109 (230)

TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Targeted inactivation of TAK1 induces more rapid muscle atrophy in male mice compared to female mice. In addition, loss of TAK1 impairs mechanical overload–induced phosphorylation of p70S6K and rpS6, leading to blunted muscle hypertrophic growth. TAK1 inactivation also promotes lipid accumulation while reducing fatty acid metabolism in skeletal muscle ...
Meiricris Tomaz da Silva, Aniket S. Joshi, Anirban Roy, Troy A. Hornberger, Ashok Kumar   +4 more
wiley   +1 more source

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

El silenciamiento génico [PDF]

, 2017
En la célula existen muchas formas de regular la expresión génica. Una de ellas es por medio del silenciamiento génico, que constituye un mecanismo celular mediante el cual se inhibe la expresión de genes, controlando la expresión de genes endógenos y ...
Sánchez, Mercedes Leonor
core   +1 more source

Aspectos del comportamiento de los triatominos (Hemiptera: Reduviidae), vectores de la enfermedad de Chagas

Biomédica, 2000
Se presenta una revisión actualizada sobre los triatominos, vectores de la enfermedad de Chagas, en aspectos como la ubicación taxonómica de las especies actualmente reconocidas, asi como de las especies encontradas en los domicilios en Colombia y del ciclo de vida del grupo en general, todo lo cual involucra el tamaño de las poblaciones, su dispersión
Wolff Echeverri, Marta Isabel, Castillo Patiño, Diana   +1 more
openaire   +5 more sources

MC BTS: Simultaneously Resolving Magnetization Transfer Effect and Relaxation for Multiple Components

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2538-2553, May 2026.
ABSTRACT Purpose To propose a signal acquisition and modeling framework for multi‐component tissue quantification that encompasses transmit field inhomogeneity, multi‐component relaxation and magnetization transfer (MT) effects. Theory and Methods By applying off‐resonance irradiation between excitation and acquisition within an RF‐spoiled gradient ...
Albert Jang, Hyungseok Jang, Nian Wang, Alexey Samsonov, Fang Liu   +4 more
wiley   +1 more source

Novel insights into the assembly of the yeast translation initiation multifactor complex: The critical role of eIF5

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The eukaryotic translation initiation is a biological process in which at least a dozen eukaryotic initiation factors (eIFs) are involved. Specifically, eIF3, eIF1, eIF5, and eIF2 as a ternary complex (eIF2‐TC) bound to GTP and methionyl initiator tRNA (Met‐tRNAiMet).
Borja Sáez de la Fuente, Laura Villamayor‐Belinchón, José Rafael Ciges‐Tomas, Marisa López‐Redondo, Carolina Espinosa, Elisabetta Boeri Erba, José L. Llácer   +6 more
wiley   +1 more source

Costos de un programa de control del vector Aedes aegypti en municipios de Colombia: el caso de Girón y Guadalajara de Buga, 2016

Cadernos de Saúde Pública, 2018
Resumen: El objetivo de este estudio fue cuantificar los costos de los programas de control de enfermedades transmitidas por vectores a nivel local en Colombia (2016).
Manuel Alejandro Salinas-López, Victoria Eugenia Soto-Rojas, Clara Beatriz Ocampo   +2 more
doaj   +1 more source

Thinking Complex Problems from a Social Approach: Epidemiological Transition and Chagas Disease [PDF]

, 2016
Considerando los factores epidemiológicos que determinan el curso de los cambios poblacionales, nos encontramos actualmente frente al fenómeno del (re)surgimiento de enfermedades infecciosas, lo que conduce a replantear ciertos marcos de análisis y de ...
Sanmartino, Mariana
core   +1 more source

Proportional Hazards Regression for Interval‐Censored Outcomes With an Interval‐Censored Covariate

Statistics in Medicine, Volume 45, Issue 10-12, May 2026.
ABSTRACT Identifying predictors for viral rebound trajectories after antiretroviral therapy (ART) interruption is central to HIV cure research. Motivated by the need to determine whether the time to achieve viral suppression after ART initiation can predict the time to viral rebound following ART interruption, we investigate modeling approaches that ...
Dongdong Li, Yue Song, Wenbin Lu, Huldrych F. Günthard, Roger Kouyos, Rui Wang   +5 more
wiley   +1 more source

Aedes albopictus en América del Sur y su relación con la distribución, y mantenimiento de enfermedades

Práctica Familiar Rural, 2016
Introducción: Ae. aegypti y Ae. albopictus son los vectores responsables de la transmisión de arbovirus en América Central y América del Sur.  Objetivo: ERevisar los principales aspectos acerca de los vectores de arbovirus (Dengue, Chikungunya, y ...
Rachel Sippy, Fernando Moreira
doaj   +1 more source